イベルメクチンをすべての患者により安全に届けるために

doi:10.1248/yakushi.20-00242

192 0 0 0 OA イベルメクチンをすべての患者により安全に届けるために

著者: 小茂田昌代
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.141, no.7, pp.887-909, 2021-07-01 (Released:2021-07-01)
参考文献数: 33
被引用文献数: 1

The difficult experience of treating scabies in an elderly hospital reaffirmed my determination and responsibilities as a pharmacist. In 2000, there was no effective treatment for scabies in Japan. With the Japan Pharmaceutical Association as well as the Japanese Dermatological Association, the indication of ivermectin which is the intestinal fecal nematode was expanded for scabies. Since it was found that the administration of ivermectin through a tube to patients who could not take it orally had a dose loss of 50% depending on the injection method, an appropriate administration method was proposed. However, the oral administration of ivermectin has side effects including systemic liver damage, and external preparations require labor for systemic application, and recurrence from unapplied areas is also a problem. Therefore, we devised a whole-body bathing, in which patients are immersed in a fluid that contains ivermectin. The repeated ivermectin bathing three times a week cured scabies and has no problematic side effects in the clinical trial, suggesting that this method is a safer treatment. Next, in Okinawa, phenothrin-resistant head lice infestation was prevalent, and no medical drug for this infestation is available in Japan yet. Hence, to address this situation, we conducted a clinical trial to investigate the efficacy and safety of a combination regimen of 5% topical phenothrin and the unapproved 0.5% topical ivermectin. Consequently, 92% and 100% effectiveness were obtained in Okinawa and Tsukuba, respectively. As a result, we were able to conduct research aimed to maximize the safety and effectiveness of ivermectin in Japan.

2023-12-13 20:52:22
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疥癬に対してイベルメクチン入浴療法というのをみつけてちょっとびっくり。そして効果があるというのを見てもっとびっくり。 https://t.co/fFzcJpNu1H

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絶食後投与に関して -高脂肪食後に服用すると血中濃度が2.57倍上昇するという報告(海外) -

2 @kuanyi_vet @yurakusai

イベルメクチンがどのように疥癬治療薬として認められるようになったかがわかる奮闘の記録イベルメクチンをすべての患者により安全に届けるために For Safer Use of Ivermectin in All Patients （東京理科大　小茂田昌代氏）YAKUGAKU ZASSHI 141, 887909 (2021) https://t.co/SkMHsOMiLR

8 @hannahumming @araran100 @looney1007 @YutakaN24620234 @boke_kora @subacco04405372 @HJfqhKAslFuqZ4n

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「イベルメクチンをすべての患者により安全に届けるために」疥癬患者に対するイベルメクチン全身浴法の考案── 「イベルメクチンの溶液に入浴すれば皮膚にイベルメクチンが直接作用でき、全身塗布する労力が不要になる」「沖縄と筑波での有効性（消失率）は92% 、100%」 https://t.co/HbdaXPDeNd

17 @595959n1 @hakorinchanman @HJfqhKAslFuqZ4n @LkfzUZ0Y6LExpTN @AkHinan @BJK49392393 @gemini_stop @husigisearch @yp_88888 @thankyoujoy @csoPsx3tDLS3pPP @goechin37 @GIRAGIRA88 @MasutaRanka @samjy15

31 @Trilliana_z @yp_88888 @595959n1 @tweettweeetjp @Itininoyon @HJfqhKAslFuqZ4n @kazuchancocone @LkfzUZ0Y6LExpTN @AkHinan @BJK49392393 @husigisearch @G5AEhSaZtjb33TE @SoGood696 @thankyoujoy @mOMK48jiU5hkmOF @csoPsx3tDLS3pPP @goechin37 @OWL321654 @tauchan_kyobash @nontan27757848 @raisebokudou @sgrandson1 @GIRAGIRA88 @MasutaRanka @ryouko_12 @HoJWYpn2Y1QEJAe @kurotuma @rOxSyUpgkNZbsCW @sakisa31565313 @newdawn66221887 @samjy15

アクセスランキングにあったこれ、なんとなく読んでみたらすごく面白かった。 J-STAGE Articles - イベルメクチンをすべての患者により安全に届けるために https://t.co/oc4e3oG2NQ

1 @ababoishi

この時期ですが疥癬治療薬としての総説です【薬学雑誌 141(7) p 887-909,2021】イベルメクチンをすべての患者により安全に届けるために https://t.co/dVrMCzmKaF

3 @shimofuripha @karenkaren2501

6 @erika_erika_220 @ring1124303 @_apple_cosme_ @hiyorin1325 @karenkaren2501 @shimofuripha

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