著者

永田 親義

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.34, no.11, pp.828-836, 1976-11-01 (Released:2009-11-13)

参考文献数

27

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Behaviors of metal enzymes, especially of Fe-porphyrin ones are considered from the quantum-biological view point. In the introductory section, historical background of quantum biology and the inevitable role ought to be played by quantum biology in studying the enzyme reaction mechanism are described, in the light of the splendid success of quantum chemistry in explaining organic reaction mechanism.In Section 2, the physical and chemical properties of the porphin and Fe-porphyrins are explained on the basis of the electronic structures of these molecules, placing special emphasis on the HOMO and LUMO and also in relation to the interaction between the molecular orbitals of Fe and porphin.In Section 3, reaction mechanism of cytochrome P-450 is discussed. By comparing the transition energies and oscilaltor strengths calculated by means of the P-P-P method with the observed optical data, the stacked models are proposed as the plausible spacial orientation between P-450 and the substrates.