10 0 0 0 OA 量子生物学 生体内電荷移動と生物活性を中心にして
- 著者
- 永田 親義
- 出版者
- 一般社団法人 日本生物物理学会
- 雑誌
- 生物物理 (ISSN:05824052)
- 巻号頁・発行日
- vol.3, no.3, pp.130-140, 1963-12-20 (Released:2009-05-25)
- 参考文献数
- 66
- 著者
- 永田 親義 今村 詮 斉藤 肇 福井 謙一
- 出版者
- The Japanese Cancer Association
- 雑誌
- GANN Japanese Journal of Cancer Research (ISSN:0016450X)
- 巻号頁・発行日
- vol.54, no.1, pp.109-117, 1963-03-31 (Released:2008-10-23)
- 参考文献数
- 23
The changes of π-electron distribution in atoms in purine bases participating in the hydrogen-bond formation in Watson-Crick model of deoxyribonucleic acid are calculated by the simple linear combination of atomic orbital-molecular orbital (LC-AO-MO) method assuming that the alkylating agents attack the guanine at its 7-N position and adenine at its 7-N and 3-N positions. The changes in electron density are believed to make an alteration of the hydrogen bond with respect to the mode of pairing. It is assumed that the tautomeric change of guanine-cytosine pair results and weakens the hydrogen bond strength of adenine-thymine pair. These changes are discussed in relation to the biological effect of alkylating agents such as mutagenic, carcinogenic, and carcinostatic activities.
- 著者
- 永田 親義 今村 詮 福井 謙一 斉藤 肇
- 出版者
- The Japanese Cancer Association
- 雑誌
- GANN Japanese Journal of Cancer Research (ISSN:0016450X)
- 巻号頁・発行日
- vol.54, no.4, pp.401-414, 1963-12-31 (Released:2008-10-23)
- 参考文献数
- 23
Results of the quantum biological study of an interaction of potent carcinogens such as 4-nitroquinoline 1-oxides and aromatic hydrocarbons with tissue components, especially with deoxyribonucleic acid (DNA), are presented and chemical carcinogenesis is discussed in connection with charge transfer phenomenon. An equation is derived to obtain the charge transfer quantity between two constituent molecules in the charge transfer complex, and distinct parallelism is found between the quantity of charge transfer and carcinogenic activity. From this result, it is suggested that the quantity of charge transfer is more important in the genesis of tumor than the charge transfer force. Summation of an alteration of base paring in Watson-Crick stereo-model of DNA resulting from the charge transfer between DNA and the carcinogens is deemed to be the cause of tumor.
2 0 0 0 OA 放射生物作用の量子化学的考察 : 色素増感突然変異 : 生体物理
- 著者
- 福田 信男 藤田 裕子 永田 親義
- 出版者
- 一般社団法人 日本物理学会
- 雑誌
- 日本物理学会春季分科会講演予稿集 1964.2 (ISSN:24331120)
- 巻号頁・発行日
- pp.375, 1964-03-31 (Released:2018-03-29)
1 0 0 0 OA 量子生物学的立場からみた金属酵素
- 著者
- 永田 親義
- 出版者
- The Society of Synthetic Organic Chemistry, Japan
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.34, no.11, pp.828-836, 1976-11-01 (Released:2009-11-13)
- 参考文献数
- 27
Behaviors of metal enzymes, especially of Fe-porphyrin ones are considered from the quantum-biological view point. In the introductory section, historical background of quantum biology and the inevitable role ought to be played by quantum biology in studying the enzyme reaction mechanism are described, in the light of the splendid success of quantum chemistry in explaining organic reaction mechanism.In Section 2, the physical and chemical properties of the porphin and Fe-porphyrins are explained on the basis of the electronic structures of these molecules, placing special emphasis on the HOMO and LUMO and also in relation to the interaction between the molecular orbitals of Fe and porphin.In Section 3, reaction mechanism of cytochrome P-450 is discussed. By comparing the transition energies and oscilaltor strengths calculated by means of the P-P-P method with the observed optical data, the stacked models are proposed as the plausible spacial orientation between P-450 and the substrates.
1 0 0 0 OA 生体高分子の量子化学
- 著者
- 永田 親義
- 出版者
- 公益社団法人 高分子学会
- 雑誌
- 高分子 (ISSN:04541138)
- 巻号頁・発行日
- vol.30, no.2, pp.107-107,94, 1981-02-01 (Released:2011-09-21)
- 参考文献数
- 4
