- 著者
-
岡田 友佳
高尾 哲也
OKADA Yuka
TAKAO Tetsuya
- 出版者
- 昭和女子大学近代文化研究所
- 雑誌
- 学苑 (ISSN:13480103)
- 巻号頁・発行日
- no.842, pp.36-40, 2010-12
The authors examined the association of the expression of taste receptors and taste blindness. Subjects were 21 female university students aged 19-21. They were tested for whether they could taste phenylthiocarbamide(PTC). Four students, or 19% of the subjects, turned out to have taste blindness where PTC is concerned. The cells in their foliate papillae were scraped between meals and were measured by RT-PCR(SCREP method). The patterns of expressions hTAS2Rs and T1R3 which are correlated with taste blindness were examined. On average, the 4 students expressed 3.25 varieties of taste receptors. Specifically, 3 students expressed hTAS2R3 which is an orphan receptor. But they did not express hTAS2R38 which is a PTC receptor. Drawing on these facts the authors suggest that hTAS2R3 might be related to bitter substances which hTAS2R38 is also related to, and that specifically hTAS2R3 might play an important role for PTC non-tasters in recognizing toxic substances which are bitter.