著者

岩見 真吾 佐藤 佳 小柳 義夫

出版者

一般社団法人日本応用数理学会

雑誌

応用数理 (ISSN:09172270)

巻号頁・発行日

vol.22, no.2, pp.85-94, 2012-06-26

---

Recently, in order to investigate the fundamental phenomena in immunology and virology such as maintenance of immune memory, T-cell homeostasis, the relationship between aging and immunosenescence, the regulation of the adaptive immune response during viral infection, the pathogenesis of CD4^+ depletion in HIV infection, and the underlying mechanisms of leukemia, we successfully quantied lymphocyte kinetics in humanized mice through BrdUlabeling experiment. It is worth noting that our findings are the first to assess lymphocyte dynamics utilizing this technique. At first, we will briefly give an outline of the "Quantification system of lymphocyte kinetics in humanized mice" and then we will discuss about properties of the lymphocyte kinetics and utilities of our established system.