- 著者
-
松田 保
小河原 緑
三浦 玲子
関 俊子
横内 正利
- 出版者
- 一般社団法人 日本血栓止血学会
- 雑誌
- 血液と脈管 (ISSN:03869717)
- 巻号頁・発行日
- vol.12, no.1, pp.13-15, 1981
Viscosity of blood at 37°C and 25°C was compared in various blood samples using coaxial cylinder viscometer which operates on the couette principle. Ratios of blood viscosity measured at 25°C to one at 37°C at shear rate of 0.39sec<sup>-1</sup> were significantly correlated with fibrinogen content of blood (n=49, r=+0.62, p<0.001). However, there was no significant correlation between ratios of blood viscosity at body temperature to one at the lower temperature and hematocrit values (n=49, r=-0.22, n. s.). To confirm important role of fibrinogen in elevation of blood viscosity when temperature falls, following experiment was carried out. Red blood cell suspentions with various amount of fibrinogen were prepared from combinations of packed red cells, bentonite adsorbed plasma, which contains no fibrinogen, normal plasma and human fibrinogen solution. Elevation of viscosity at 25°C was more pronounced when amount of fibrinogen in the suspension increased.<br>Significance of elevated viscosity of blood with increased fibrinogen content at low temperature in development of Raynaud's phenomenon was discussed.