著者
松田 保 小河原 緑 三浦 玲子 関 俊子
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.15, no.2, pp.207-209, 1984
被引用文献数
1

Levels of fibrinogen, plasminogen, antithrombin III, &alpha;<sub>2</sub>-plasmin inhibitor and &alpha;<sub>2</sub>-macroglobulin in plasma were determined using single radial immunodiff usion method in an old people's home in 1979, 1981 and 1982. Comparison of results of these parameters in the same subjects between in 1981 and 1982 was possible in 67 subjects. Comparison between in 1979 and 1981 was done in 61 subjects. Results of coagulation analysis in 1979 and 1982 were compared in 49 subjects.<br>Generally, concentrations of plasminogen, antithrombin III and &alpha;<sub>2</sub>-plasmin inhibitor in plasma were higher in women than in men. There were statistically significant correlations between all the parameters determined at intervals of 1, 2 and 3 years in the same subjects. The coefficients of correlation in each parameter at intervals of 1 to 3 years were as follows: +0.45-+0.57 in fibrinogen, +0.69-+0.81 in plasminogen, +0.55-+0.81 in antithrombin III, +0.46-+0.64 in &alpha;<sub>2</sub>-plasmin inhibitor and +0.91-+0.93 in alpha;<sub>2</sub>-macroglobulin. From these results, it is concluded that old women are generally less thrombotic than old men and that there is some &ldquo;individuality&rdquo; in patterns of the parameters affecting blood coagulation and fibrinolysis in the elderly. The significance of the &ldquo;individuality&rdquo; upon prognosis of the elderly was discussed.
著者
松田 保 小河原 緑 平林 直子 関 俊子 横内 正利 村上 元孝 島田 馨 三船 順一郎
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.9, no.2, pp.208-212, 1978

Recently, growing interests had been devoted largely to disseminated intravascular coagulation (DIC), because of its frequency and clinical importance. It has been known that shock is a frequent complication of DIC, although it has not been elucidated whether shock is a cause of DIC rather than a result. This study was made to clarify relationship between DIC and shock in 699 consecutive autopsied cases, almost all of whom was over age sixty, in Tokyo Metropolitan Geriatric Hospital.<br>The diagnosis of DIC was established when coagulation analysis revealed presence of consumption coagulopathy. Among these cases, 106 had evidences of DIC and 30 had clinical and pathological findings highly suggestive of DIC although the coagulation findings were not specific. Shock was complicated in 38 of the former and 10 of the latter.<br>Eight of these 48 patients with DIC complicated with shock revealed consumption coagulopathy simultaneously with the development of shock. 24 cases had not clea r-cut evidences of DIC immediately after the development of shock in coagulation findings, although they showed marked coagulation abnormalities indicating DIC after the shock developed. 44% of conditions associated with the shock in these patients was gram-negative septicaemia. The other underlying pathologic conditons in these cases consisted of cancer, peptic ulcer, acute myocardial infarction and pneumonia.<br>Onset of shock was observed in 16 cases in whom diagnosis of DIC had been already established by coagulation analysis. 11 cases of these had cancer with metastases, primary organs of which were stomach, colon or biliary tracts. 70% of these patients were febrile.<br>Acute renal failure, purpura, petechiae, melena, coma, epileptic seizure, systemic peripheral gangrene and/or red cell fragmentation in peripheral blood smear were main symptoms in DIC with shock. Four cases, excluding two cases in whom DIC developed following development of acute myocardial infarction, showed ECG findings indicating development of acute myocardial infartion, although myocardial infarction was evident in only one cases by postmortem examination.<br>Presence of fibrin thrombi was confirmed in 36 cases out of the 48 autopsied cases with DIC accompained with shock. Terminal hemorrhagic necrotizing enteropathy was observed in 15 of those cases. Hemorrhage from adrenal was observed in 4 cases.<br>From these results, it is concluded that shock does frequently cause DIC and that shock in gram-negative septicaemia is especially important because of its high incidence to result DIC.
著者
松田 保 小河原 緑 三浦 玲子 関 俊子 横内 正利
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.12, no.1, pp.13-15, 1981

Viscosity of blood at 37&deg;C and 25&deg;C was compared in various blood samples using coaxial cylinder viscometer which operates on the couette principle. Ratios of blood viscosity measured at 25&deg;C to one at 37&deg;C at shear rate of 0.39sec<sup>-1</sup> were significantly correlated with fibrinogen content of blood (n=49, r=+0.62, p<0.001). However, there was no significant correlation between ratios of blood viscosity at body temperature to one at the lower temperature and hematocrit values (n=49, r=-0.22, n. s.). To confirm important role of fibrinogen in elevation of blood viscosity when temperature falls, following experiment was carried out. Red blood cell suspentions with various amount of fibrinogen were prepared from combinations of packed red cells, bentonite adsorbed plasma, which contains no fibrinogen, normal plasma and human fibrinogen solution. Elevation of viscosity at 25&deg;C was more pronounced when amount of fibrinogen in the suspension increased.<br>Significance of elevated viscosity of blood with increased fibrinogen content at low temperature in development of Raynaud's phenomenon was discussed.