著者
松田 保 小河原 緑 三浦 玲子 関 俊子
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.15, no.2, pp.207-209, 1984
被引用文献数
1

Levels of fibrinogen, plasminogen, antithrombin III, &alpha;<sub>2</sub>-plasmin inhibitor and &alpha;<sub>2</sub>-macroglobulin in plasma were determined using single radial immunodiff usion method in an old people's home in 1979, 1981 and 1982. Comparison of results of these parameters in the same subjects between in 1981 and 1982 was possible in 67 subjects. Comparison between in 1979 and 1981 was done in 61 subjects. Results of coagulation analysis in 1979 and 1982 were compared in 49 subjects.<br>Generally, concentrations of plasminogen, antithrombin III and &alpha;<sub>2</sub>-plasmin inhibitor in plasma were higher in women than in men. There were statistically significant correlations between all the parameters determined at intervals of 1, 2 and 3 years in the same subjects. The coefficients of correlation in each parameter at intervals of 1 to 3 years were as follows: +0.45-+0.57 in fibrinogen, +0.69-+0.81 in plasminogen, +0.55-+0.81 in antithrombin III, +0.46-+0.64 in &alpha;<sub>2</sub>-plasmin inhibitor and +0.91-+0.93 in alpha;<sub>2</sub>-macroglobulin. From these results, it is concluded that old women are generally less thrombotic than old men and that there is some &ldquo;individuality&rdquo; in patterns of the parameters affecting blood coagulation and fibrinolysis in the elderly. The significance of the &ldquo;individuality&rdquo; upon prognosis of the elderly was discussed.
著者
松田 保 小河原 緑 三浦 玲子 関 俊子 横内 正利
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.12, no.1, pp.13-15, 1981

Viscosity of blood at 37&deg;C and 25&deg;C was compared in various blood samples using coaxial cylinder viscometer which operates on the couette principle. Ratios of blood viscosity measured at 25&deg;C to one at 37&deg;C at shear rate of 0.39sec<sup>-1</sup> were significantly correlated with fibrinogen content of blood (n=49, r=+0.62, p<0.001). However, there was no significant correlation between ratios of blood viscosity at body temperature to one at the lower temperature and hematocrit values (n=49, r=-0.22, n. s.). To confirm important role of fibrinogen in elevation of blood viscosity when temperature falls, following experiment was carried out. Red blood cell suspentions with various amount of fibrinogen were prepared from combinations of packed red cells, bentonite adsorbed plasma, which contains no fibrinogen, normal plasma and human fibrinogen solution. Elevation of viscosity at 25&deg;C was more pronounced when amount of fibrinogen in the suspension increased.<br>Significance of elevated viscosity of blood with increased fibrinogen content at low temperature in development of Raynaud's phenomenon was discussed.