文献一覧: 小河原緑 (著者)

1 0 0 0 老人ホーム在住者の凝固線溶能の経年変化

著者: 松田保小河原緑三浦玲子関俊子
出版者: 一般社団法人日本血栓止血学会
雑誌: 血液と脈管 (ISSN:03869717)
巻号頁・発行日: vol.15, no.2, pp.207-209, 1984
被引用文献数: 1

Levels of fibrinogen, plasminogen, antithrombin III, α2-plasmin inhibitor and α2-macroglobulin in plasma were determined using single radial immunodiff usion method in an old people's home in 1979, 1981 and 1982. Comparison of results of these parameters in the same subjects between in 1981 and 1982 was possible in 67 subjects. Comparison between in 1979 and 1981 was done in 61 subjects. Results of coagulation analysis in 1979 and 1982 were compared in 49 subjects. Generally, concentrations of plasminogen, antithrombin III and α2-plasmin inhibitor in plasma were higher in women than in men. There were statistically significant correlations between all the parameters determined at intervals of 1, 2 and 3 years in the same subjects. The coefficients of correlation in each parameter at intervals of 1 to 3 years were as follows: +0.45-+0.57 in fibrinogen, +0.69-+0.81 in plasminogen, +0.55-+0.81 in antithrombin III, +0.46-+0.64 in α2-plasmin inhibitor and +0.91-+0.93 in alpha;2-macroglobulin. From these results, it is concluded that old women are generally less thrombotic than old men and that there is some “individuality” in patterns of the parameters affecting blood coagulation and fibrinolysis in the elderly. The significance of the “individuality” upon prognosis of the elderly was discussed.

2020-08-31 16:51:16
1 + 1 Wikipedia

1 0 0 0 血管内凝固症候群とショック

著者: 松田保小河原緑平林直子関俊子横内正利村上元孝島田馨三船順一郎
出版者: 一般社団法人日本血栓止血学会
雑誌: 血液と脈管 (ISSN:03869717)
巻号頁・発行日: vol.9, no.2, pp.208-212, 1978

Recently, growing interests had been devoted largely to disseminated intravascular coagulation (DIC), because of its frequency and clinical importance. It has been known that shock is a frequent complication of DIC, although it has not been elucidated whether shock is a cause of DIC rather than a result. This study was made to clarify relationship between DIC and shock in 699 consecutive autopsied cases, almost all of whom was over age sixty, in Tokyo Metropolitan Geriatric Hospital. The diagnosis of DIC was established when coagulation analysis revealed presence of consumption coagulopathy. Among these cases, 106 had evidences of DIC and 30 had clinical and pathological findings highly suggestive of DIC although the coagulation findings were not specific. Shock was complicated in 38 of the former and 10 of the latter. Eight of these 48 patients with DIC complicated with shock revealed consumption coagulopathy simultaneously with the development of shock. 24 cases had not clea r-cut evidences of DIC immediately after the development of shock in coagulation findings, although they showed marked coagulation abnormalities indicating DIC after the shock developed. 44% of conditions associated with the shock in these patients was gram-negative septicaemia. The other underlying pathologic conditons in these cases consisted of cancer, peptic ulcer, acute myocardial infarction and pneumonia. Onset of shock was observed in 16 cases in whom diagnosis of DIC had been already established by coagulation analysis. 11 cases of these had cancer with metastases, primary organs of which were stomach, colon or biliary tracts. 70% of these patients were febrile. Acute renal failure, purpura, petechiae, melena, coma, epileptic seizure, systemic peripheral gangrene and/or red cell fragmentation in peripheral blood smear were main symptoms in DIC with shock. Four cases, excluding two cases in whom DIC developed following development of acute myocardial infarction, showed ECG findings indicating development of acute myocardial infartion, although myocardial infarction was evident in only one cases by postmortem examination. Presence of fibrin thrombi was confirmed in 36 cases out of the 48 autopsied cases with DIC accompained with shock. Terminal hemorrhagic necrotizing enteropathy was observed in 15 of those cases. Hemorrhage from adrenal was observed in 4 cases. From these results, it is concluded that shock does frequently cause DIC and that shock in gram-negative septicaemia is especially important because of its high incidence to result DIC.

2020-08-31 16:51:16
1 + 1 Wikipedia

1 0 0 0 老年者の血液粘度

著者: 松田保児玉直子秀野啓子小河原緑松崎俊久村上元孝山之内博
出版者: 一般社団法人日本血栓止血学会
雑誌: 血液と脈管 (ISSN:03869717)
巻号頁・発行日: vol.7, no.2, pp.146-150, 1976

Apparent blood viscosity was measured on freshly shed blood from 127 healthy subjects, ages 21 to 88, and patients hospitalized in Tokyo Metropolitan Yoikuin Geriatrics Hospital, over age 60. Determination of blood viscosity was performed at 37°C using rotational viscometer at shear rates between 0.07 and 4.6sec-1. Mean blood viscosity in 43 healthy older subjects over age 60 (mean age: 74±6) was 45±25cp at 0.07sec-1 and 8±2cp at 4.6sec-1, respectively. Yield stress was calculated from Casson plot at very low shear rates (between 0.44 and 0.07sec-1) by the method of least squares. Mean value of yield stress in the healthy older subjects was 0.011 dynes/cm2. Blood viscosity in the healthy subjects was significantly correlated with hematocrit values. Yield stress in these subjects was also correlated with hematocrit values and blood viscosity at very low shear rates. In these healthy subjects, blood viscosity, yield stress and hematocrit values were highest in the group at age 30-39. Blood viscosity and yield stress showed a slight decline with age in the healthy older subjects. In the hospitalized patients, blood viscosity was higher than 70cp at 0.07sec-1, and/or higher than 11cp at 4.6sec-1 in 107 measurements (86 cases) out of 1443 determinations from December 1973 to October 1974. These patients with blood high viscosity included 12 cases of cancer (one of them was accompanied with disseminated intravascular coagulation (DIC); three of them developed DIC thereafter), 5 cases of acute myocardial infarction, 4 cases of acute cerebral infarction, 5 cases of angina pectoris, 6 cases of old myocardial infarction, 18 cases of old cerebrovascular diseases, 11 cases of diabetes mellitus, and 5 cases of stress polycythemia or polycythemia vera. In these cases, viscosity at 4.6sec-1 was significantly correlated with hematocrit values, whereas viscosity at 0.07sec-1 was not. All patients with blood high viscosity and relatively low hematocrit values suffered from cancer. In 6 cases of acute myocardial, cerebral of renal infarction, in whom changes in blood viscosity, yield stress and hematocrits were investigated before and after the development of infarction, changes in blood viscosity and yield stress were parallel with hematocrits. From these results, it was concluded that high hematocrits caused blood high viscosity and were regarded as one of the risk factors in the pathogenesis of thrombosis, although the other factors than hematocrits might also influence blood viscosity at very low shear rates.

2020-08-31 16:51:16
1 + 1 Wikipedia

1 0 0 0 血液粘度の低温における変化とその意義

著者: 松田保小河原緑三浦玲子関俊子横内正利
出版者: 一般社団法人日本血栓止血学会
雑誌: 血液と脈管 (ISSN:03869717)
巻号頁・発行日: vol.12, no.1, pp.13-15, 1981

Viscosity of blood at 37°C and 25°C was compared in various blood samples using coaxial cylinder viscometer which operates on the couette principle. Ratios of blood viscosity measured at 25°C to one at 37°C at shear rate of 0.39sec-1 were significantly correlated with fibrinogen content of blood (n=49, r=+0.62, p<0.001). However, there was no significant correlation between ratios of blood viscosity at body temperature to one at the lower temperature and hematocrit values (n=49, r=-0.22, n. s.). To confirm important role of fibrinogen in elevation of blood viscosity when temperature falls, following experiment was carried out. Red blood cell suspentions with various amount of fibrinogen were prepared from combinations of packed red cells, bentonite adsorbed plasma, which contains no fibrinogen, normal plasma and human fibrinogen solution. Elevation of viscosity at 25°C was more pronounced when amount of fibrinogen in the suspension increased. Significance of elevated viscosity of blood with increased fibrinogen content at low temperature in development of Raynaud's phenomenon was discussed.

2020-08-31 16:51:16
1 + 1 Wikipedia