著者

池田 知穗 中原 良介 西岡 有佳 黒川 央 山口 敬子 藤田 芳一

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.58, no.8, pp.675-679, 2009 (Released:2009-10-09)

参考文献数

20

被引用文献数

2

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陰イオン性界面活性剤のドデシル硫酸ナトリウム共存下,色素のピロガロールレッド(PR)と金属イオンのモリブデン(VI)間で生成する呈色錯体の退色を利用する亜硝酸イオンの簡便で高感度な吸光光度定量法を開発した.本法は,0.04~0.46 μg mL-1亜硝酸イオン濃度範囲でBeerの法則が成立し,みかけのモル吸光係数は1.0×105 L mol-1 cm-1と高感度であり,亜硝酸イオン0.23 μg mL-1での6回での相対標準偏差は1.92%(n=6,0.23 μg mL-1)と再現性にも比較的優れていた.

著者

小野 寛之 佐藤 雄己 大山 展弘 中原 良介 倉成 正恵 伊東 弘樹

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.1, pp.7-12, 2016 (Released:2016-06-13)

参考文献数

8

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Background: Because generic medicines reduce the financial burden on patients and medical insurance providers, they become more popular year after year.  However, there are still few reports that analyze the efficacy and safety of generic medicines, especially in terms of their characteristics and side effects.Methods: Paclitaxel is an antineoplastic frequently used with good results in the treatment of breast cancer, ovarian cancer, gastric cancer, and angiosarcoma, but fat solubility is high and various kinds of adverse events, such as myelosuppression and arthralgia, peripheral neuropathy, and alcohol hypersensitivity are known to develop.  We investigated the efficacy, characteristics, and the incidence of adverse events for the generic product of paclitaxel.Results: Differences were found for the generic version in terms of the characteristics and preparation time.Conclusion: The incidence of adverse events was not significant, suggesting that the generic version could be a reasonable substitute.