著者

遠山 泰崇 佐藤 雄己 鈴木 陽介 田辺 三思 竹中 隆一 和田 伸介 石井 圭亮 伊東 弘樹

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.8, pp.594-599, 2015-08-10 (Released:2016-08-10)

参考文献数

18

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We report the cases of 10 patients with acute lithium intoxication who were treated over the past 6 years. The range of lithium overdose was 600 mg to 9,600 mg and the lithium concentration of all cases was greater than the toxic concentration. Three of the 10 cases were treated with fluid therapy. Another 3 cases were treated with continuous hemodiafiltration (CHDF). The rest were treated with hemodialysis (HD). The serum lithium concentration of the 3 patients with fluid therapy gradually decreased. However, it took 24 hours after the treatment to reach the therapeutic level in Case 2 since the slope was comparatively loose. In the meantime, the high lithium concentration of patients with CHDF (Cases 4, 8, 10) and HD rapidly decreased and it finally reached the therapeutic level. But a post-dialysis rebound effect in the lithium concentration was detected in Case 9. This report shows that CHDF and HD is an effective and sufficient treatment for lowering the serum concentration of lithium in a short period in acute lithium toxicity. As the serum lithium concentration of a patient with HD often rebounds and repeated or prolonged treatment may be required, we reaffirmed the patient's condition. Thus, completion of HD should be judged based on not only serum lithium concentration but also sufficient observation of the clinical course.

著者

伊東 弘樹

雑誌

学習院大学大学院日本語日本文学 (ISSN:13499386)

巻号頁・発行日

no.17, pp.17-32, 2021-03

著者

小野 寛之 佐藤 雄己 大山 展弘 中原 良介 倉成 正恵 伊東 弘樹

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.1, pp.7-12, 2016 (Released:2016-06-13)

参考文献数

8

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Background: Because generic medicines reduce the financial burden on patients and medical insurance providers, they become more popular year after year.  However, there are still few reports that analyze the efficacy and safety of generic medicines, especially in terms of their characteristics and side effects.Methods: Paclitaxel is an antineoplastic frequently used with good results in the treatment of breast cancer, ovarian cancer, gastric cancer, and angiosarcoma, but fat solubility is high and various kinds of adverse events, such as myelosuppression and arthralgia, peripheral neuropathy, and alcohol hypersensitivity are known to develop.  We investigated the efficacy, characteristics, and the incidence of adverse events for the generic product of paclitaxel.Results: Differences were found for the generic version in terms of the characteristics and preparation time.Conclusion: The incidence of adverse events was not significant, suggesting that the generic version could be a reasonable substitute.

著者

伊東 弘樹

雑誌

学習院大学国語国文学会誌

巻号頁・発行日

no.61, pp.49-65, 2018-03-15

著者

遠原 大地 後藤 玲子 伊東 弘樹 森 一生 鳥越 繁治 中川 辰二 因泥 栄一郎 武山 正治

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.30, no.4, pp.255-260, 2004-04-10

被引用文献数

2 2

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We developed a support system for pharmaceutical counseling services using a handheld computer loaded with HS-WIN. HS-WIN is standard software for pharmaceutical counseling services that is compatible with Windows X-P, 2000 and 98. Our support system is linked to the pharmacy network system of Oita University Hospital. It enables various kinds of information to be retrieved from the pharmacy network system and shown on the display of a handheld computer. This includes drug information, names, sex, birth dates, heights and weights of patients as well as clinical department and ward-related information. The handheld computers are the VAIO PCG-U 1 and PCG-U 3 (SONY, Inc.) and they are used at the bedside. To evaluate the effectiveness of our system,we measured the time required for the management of medication histories and patient counseling records for three wards.The system was able to reduce the time required per patient by an average of 34 minutes.