著者

住田 知樹 加藤 友美 吉村 友秀 村瀬 隆一 中城 公一 浜川 裕之

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.55, no.9, pp.463-466, 2009-09-25 (Released:2012-08-28)

参考文献数

14

被引用文献数

3 7

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Methotrexate (MTX) has been proven to be effective for the treatment of rheumatoid arthritis (RA)and is believed to be nononcogenic when a low weekly dose is administered to patients with RA. However, wereport the case of a 71-year-old man with RA who was treated for 11 years with MTX and developed B cell non-Hodgkin's lymphoma (BNHL) in the oral cavity. The tumor was localized in the right maxilla extranodally.Microscopic examination of a biopsy specimen revealed a non-epithelial tumor pattern and showed BNHL inwhich large cells with pleomorphic nuclei invaded the muscle tissue. These large cells tested strongly positive forEpstein-Barr virus encoded small RNAs-in situ hybridization (EBER-ISH) and CD20 antibody. We immediatelystopped MTX administration; however, only minimal shrinkage of the tumor was observed. Therefore, we performedantibody treatment with rituximab. After chemotherapy, complete remission was achieved. To date, thepatient is healthy, with no evidence of tumor recurrence during 32 months of follow-up. The development of anextranodal lymphoma in the oral cavity in a patient with RA who received MTX has not been reported previously.Therefore, this case is considered extremely rare.

著者

寺門 永顕 新谷 悟 原 慎吾 篠原 裕志 矢野 淳也 栢原 浩彰 中城 公一 日野 聡史 浜川 裕之

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.2, pp.76-82, 2003-08-01 (Released:2010-06-08)

参考文献数

8

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The efficacy of azithromycin as a chemoprophylactic agent for acute dental infection was assessed, and a questionnaire survey about the impression of azithromycin was conducted. METHODS: Eighty-three patients were given 500 mg of azithromycin for three days. Seven days after the onset of the treatment, we evaluated the clinical symptoms and collected the questionnaires. RESULTS: Clinical efficacy was observed in 89.2% of the patients, and that by questionnaire was 86.7%. Diarrhea as a side effect was seen in two patients. In the questionnaire, 79% of patients noted its effect from the second to fourth day after the medication. Although half of the patients did not care about the convenience, of taking the medication once a day, which is one of the advantages of azithromycin, most of the patients were satisfied with its efficacy.Furthermore, 72.3% of patients considered azithromycin to be significantly more acceptable compared with other antibiotics. CONCLUSION : Azithromycin is a useful therapeutic regimen for the treatment of acute dental infections.