著者

山國 徹 中島 晶 大泉 康

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.4, pp.517-520, 2010 (Released:2010-04-01)

参考文献数

11

被引用文献数

4 14

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Alzheimer's disease (AD) has become a major health burden to society. However, no fundamentally therapeutic drugs for AD have been developed. Increasing evidence suggests that the elevation of β-amyloid (Aβ) peptides in the brain is central to AD pathogenesis. Recently, in the course of our survey of substances having anti-dementia activity from natural resources, we have successfully found nobiletin, a polymethoxylated flavone contained in AURANTII NOBILIS PERICARPIUM which is a component of traditional Chinese medicines. In this review, we describe the beneficial effects of nobiletin on memory impairment and Aβ pathology in a transgenic mouse model introduced human “Swedish” and “London” mutant amyloid precursor protein. We also note the possible molecular mechanism underlying the protective action against Aβ-induced memory impairment provided by our studies using cultured hippocampal neurons. Namely, daily administration of nobiletin for four months rescued the memory impairment in fear conditioning, and decreased hippocampal Aβ deposit in the transgenic mice as analyzed by immunohistochemistry. PKA-dependent signaling and membrane trafficking of AMPA receptor subunit, GluR1, which are known to be required for long-term potentiation (LTP), have been demonstrated to be inhibited by a sublethal concentration of Aβ in cultured hippocampal neurons. Our in vitro studies evidently showed that a sublethal concentration of Aβ actually inhibited glutamate-induced increases in both PKA substrates phosphorylation and GluR1 membrane trafficking in cultured hippocampal neurons, whereas nobiletin reversed the Aβ-induced inhibition of such biochemical processes. The natural compound with these unique actions has thus potential to become a novel drug for fundamental treatment of AD.

著者

中島 晶 久保田 祥 佐々木 克彦 柳沢 祐介 岸 恭弘

出版者

一般社団法人 日本機械学会

雑誌

M&M材料力学カンファレンス

巻号頁・発行日

vol.2017, 2017

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<p>The subject of this paper is to calculate the residual stress occurred during heat treatments of the large forged steel using Finite Element Method (FEM). The analysis was carried out using a cylindrical FEM model of ASTM-A-470 used in rotor shafts for power stations. First, a heat transfer analysis was performed to obtain a temperature history, which is used to calculate material properties at varied temperatures. Then, using the temperature history, structure analyses were conducted considering both the creep deformation and the transformation plasticity. The residual stresses calculated by the structure analysis were compared with the value measured by experiments. As a result, the calculated residual stresses have the same tendency as the measured residual stresses when both the creep and transformation plasticity are considered. Therefore, the importance of both the creep and transformation plasticity for the structural analysis of the heat treatment of the large forged steels was confirmed. In addition, the effect of the cooling rate to the residual stress was also discussed.</p>

著者

中島 晶 眞野 成康 富岡 佳久 山口 浩明

出版者

名古屋大学

雑誌

基盤研究(B)

巻号頁・発行日

2008

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新たに見出された薬物トランスポーターSLC10A4の安定発現細胞を作製し、胆汁酸であるケノデオキシコール酸およびウルソデオキシコール酸の輸送に寄与することを明らかにした。SLC10A4を発現している小脳由来TE671細胞を用い機能解析を行った結果、プロテアーゼであるトロンビンによってタウロコール酸の輸送活性が上昇することを発見し、その基質結合能が既知の胆汁酸トランスポーターに比較して高いことを明らかにした。

著者

安住 拓哉 中島 晶子

出版者

朝日新聞出版

雑誌

Aera = アエラ (ISSN:09148833)

巻号頁・発行日

vol.32, no.3, pp.10-13, 2019-01-21