著者

中村 優一 角田 直人 山田 幸生

出版者

一般社団法人 日本機械学会

雑誌

年次大会講演論文集

巻号頁・発行日

vol.2003, pp.65-66, 2003

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Water as well as wastes is removed from the blood of patients under dialysis treatment. If the quantity of the removed water exceeds the limit by some reasons the probability of dangerous accidents becomes high. Therefore, it is highly desired to monitor the blood status continuously during dialysis treatment. This paper presents some results of a fundamental research of measurement of water content in blood using near infrared spectroscopy and multivariate analysis for the purpose of continuous blood monitoring.

著者

千田 浩司 荒井 ひろみ 井口 誠 小栗 秀暢 菊池 浩明 黒政 敦史 中川 裕志 中村 優一 西山 賢志郎 野島 良 長谷川 聡 波多野 卓磨 濱田 浩気 古川 諒 山田 明 渡辺 知恵美

雑誌

コンピュータセキュリティシンポジウム2020論文集

巻号頁・発行日

pp.1245-1252, 2020-10-19

著者

中村 優一 馬岡 秀陽 上岡 麗子 池田 剛 塚本 佐知子

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

vol.52, pp.505-510, 2010

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We reported the structures and biosynthetic experiments of prenylated indole alkaloids, notoamides, which isolated from a marine-derived fungus Aspergillus sp. Among them, notoamides A and B (1 and 2) and stephacidin A (6) contain a bicyclo[2.2.2]diazaoctane ring, which is proposed to be constructed from notoamice E (8) by the intramolecular Diels-Alder (IMDA) reaction. We made a feeding experiment of ^<13>C-labeled-8 in the minimum medium. Contrary to our expectaton, compounds containing a bicyclo ring were not obtained at all. This result suggested that the formation of a pyrane ring would be constructed after the formation of the bicyclo ring. Then, we made a feeding experiment of ^<13>C, ^<15>N-labeled-7, which lacks a pyrane ring in 6. As the result, a pinacol-type rearrangement of the isoprenyl group in 7 occurred to give 11 and 12, and no metabolite containing a bicyclo ring was afforded. Now, feeding experiments of ^<13>C, ^<15>N-labeled-11 and -12 are in progress. Nortoamides O-R (14-17) were isolated from the same extract of the fungus, which yielded other notoamides. Notoamide O (14) possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids. The structure represents an unusual branc point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway.

著者

肥爪 彰夫 倉田 健二 中村 優一 松田 隆男

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集C編 (ISSN:03875024)

巻号頁・発行日

vol.58, no.554, pp.2869-2876, 1992

被引用文献数

1

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Excessively large transient torsional vibration is induced on the rotor system of modern large turbine-generators. This paper reveals that the coupling connecting the adjacent rotors acts as a hysteresis damper, and discusses the effect. First, a model is presented for the damping mechanism of typical shaft coupling. Second, the time-dependent nonlinear transient torsional vibration of the rotor system is investigated, using this model. Third, an improved coupling of higher damping capacity is introduced and investigated in the same way. Thus, the proper direction of the optimal design of coupling is clearly specified.

著者

北野 正典 中村 優一 PILT Kristjan 有本 英伸 角田 直人 山田 幸生

出版者

一般社団法人 日本機械学会

雑誌

年次大会講演論文集

巻号頁・発行日

vol.2005, pp.61-62, 2005

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Patients of kidney disease remove excess water by hemodialysis. In hemodialysis, blood pressure may fall and the patients may suffer from hypovolemic shock, because body fluid removal rate is normally larger than plasma refilling rate. The aim of our research is to measure water content in issue in order to prevent the hypovolemic shock and to know how much water has to be removed quantitatively. We employ a technique using near infrared spectroscopy for this purpose. It will have advantages of being real-time, noninvasive and continuous.

著者

中村 優一 加藤 光 塚本 佐知子

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

vol.53, pp.421-426, 2011

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In our laboratory, we search for drug leads from marine sponge, ascidian and fungus. The extract of the ascidian Didemnum sp., which collected in Indonesia in 2006, showed anti-fungal activity and inhibitory activity of p53-Mdm2 complex formation. p53, tumor suppressor, protein induced growth arrest and apoptosis, and Mdm2 is an E3 for p53 protein. Therefore, inhibition of p53-Mdm2 complex formation is a promising approach for treatment of cancer. Twelve new serinolipids, 1-12 were isolated from Indonesian ascidian Didemnum sp. 1D and 2D NMR spectrum and MS spectrum analysis was revealed the structures of these compounds possessing a 6,8-dioxabicyclo[3.2.1]octane ring, which was appeared in didemniserinolipid A, a glycerophosphocholine moiety and a serinol moiety containing sulfate. Compounds 1-12 demonstrated inhibition of p53-Mdm2 complex formation. Compounds 1 and 5 were the most potent inhibitors with an IC^<50> value of 2.0 μM, while compounds -2 and 10 exhibited weak inhibitors with IC^<50> values of 53 and 55 μM, respectively.