著者

中村 寛海 西川 禎一

出版者

Osaka Urban Living and Health Association

雑誌

生活衛生 (ISSN:05824176)

巻号頁・発行日

vol.50, no.4, pp.175-184, 2006 (Released:2006-08-08)

参考文献数

39

被引用文献数

2

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Listeria monocytogenes is the causative agent of foodborne listeriosis in humans. Japan has an average of 83 cases of listeriosis per year and an estimated incidence of 0.65 cases per million residents, which is lower than the values reported in some European countries and the United States. Nevertheless, the level of contamination in retail food products in Japan is roughly equivalent to that reported in these countries, where large outbreaks have occurred. Japan might therefore face a similar risk of foodborne listeriosis outbreaks. Ready-to-eat seafood (such as cold-smoked fish) has been linked to sporadic cases of listeriosis. In Japan, a wide range of ready-to-eat seafood products are consumed in great quantities. We investigated L. monocytogenes contamination in commercially available ready-to-eat seafood products during 1999 and 2000. L. monocytogenes was isolated from 13% (12 of 95) of the tested products. All the positive samples were cold-smoked fish products. Molecular typing of the isolates suggested that the products were contaminated with persistent strains that were unique to their respective manufacturers. We investigated manufacturing plant A to trace L. monocytogenes isolates to the source of contamination. As the result of this, a combined analysis of the seasonal prevalence of this bacterium and molecular typing of the isolates in the plant suggested that the product contamination was associated with the slicing machines. Implementation of an effective washing and cleaning regime for the slicing machines resulted in a marked decrease in the incidence of L. monocytogenes contamination of the finished products.

著者

朝倉 宏 中村 寛海

出版者

国立医薬品食品衛生研究所

雑誌

基盤研究(C)

巻号頁・発行日

2019-04-01

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本研究では,食品媒介性感染症として世界中で多発するカンピロバクターがヒト生体内での感染過程で顕す遺伝子発現及び腸内細菌叢の動態を発症患者由来検体を研究対象にプロファイル化し,疫学情報及び原因菌株のゲノム特性と融合を通じ,本菌感染に伴う病態発現の分子基盤に係る基礎知見の集積を図ることを目的としている。ヒト腸管環境において本菌が顕す病態形成機構は依然として不明な点が多く、主たる病原因子の同定並びに微生物間クロストークに関する分子解明,ひいては予防治療に資する標的分子の特定や腸管環境下の細菌叢調節を通じた感染制御策の構築等へと波及することが期待される。