著者

虎石 顕一 中村 規子 由井薗 陽一 森 真弓 山田 正紀 高橋 司 黒川 美智子

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.24, no.5, pp.479-483, 1998-10-10 (Released:2011-08-11)

参考文献数

12

被引用文献数

12 9

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In order to improve children's compliance in taking bitter medicine, a gel base confectionery, which immediately changes into a jelly from after adding a special liquid, was used to mask the characteristic taste of the medicament. In pre-clinical trials, this jelly was evaluated by six adult volunteers who all reported the bitter taste to distinctly disappear in the jelly-formed quinia compared to a the powder of this medicine. Furthermore, we confirmed no comparable changes to exist in the serum levels of acetaminophene between acetaminophene alone and the gelbasemedicament mixture by oral administration. A clinical trial in three pediatric patients, who usually refuse medication because the bitter taste of the drugs, resulted in a 100% drug compliance for these children.