31 0 0 0 OA 服薬拒否小児のコンプライアンス向上のための市販菓子用即時型ゲル基剤の臨床応用
- 著者
- 虎石 顕一 中村 規子 由井薗 陽一 森 真弓 山田 正紀 高橋 司 黒川 美智子
- 出版者
- 一般社団法人 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.24, no.5, pp.479-483, 1998-10-10 (Released:2011-08-11)
- 参考文献数
- 12
- 被引用文献数
- 12 9
In order to improve children's compliance in taking bitter medicine, a gel base confectionery, which immediately changes into a jelly from after adding a special liquid, was used to mask the characteristic taste of the medicament. In pre-clinical trials, this jelly was evaluated by six adult volunteers who all reported the bitter taste to distinctly disappear in the jelly-formed quinia compared to a the powder of this medicine. Furthermore, we confirmed no comparable changes to exist in the serum levels of acetaminophene between acetaminophene alone and the gelbasemedicament mixture by oral administration. A clinical trial in three pediatric patients, who usually refuse medication because the bitter taste of the drugs, resulted in a 100% drug compliance for these children.
1 0 0 0 OA ペン型注入器用注射針変更による患者使用感の違いに関する検討
- 著者
- 二神 咲子 由井薗 陽一 槙林 智子
- 出版者
- 一般社団法人日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.41, no.9, pp.624-629, 2015-09-10 (Released:2016-09-10)
- 参考文献数
- 8
The self-injection of insulin or GLP-1 receptor agonists causes mental distress to patients, and pen-type injectors and their needles are being continually developed and improved to alleviate such distress. In Saiseikai Fukuoka General Hospital, Nanopass® 34G Needle II 4 mm (T34) , the thinnest needle available on the market, has been used. To examine usability for patients after changing the injector needle from BD Micro-Fine PlusTM 31G 5 mm (BD31) or Nanopass® 33G Needle 5 mm (T33) to T34, a questionnaire survey was conducted. Sensitive patients perceived differences when changing their injector needles not only from BD31 to T34, with a difference of 3G, but also from T33 to T34, with a smaller difference of 1G. In both cases, patients' perceptions improved as a result of improvements in factors markedly influencing them: frequency of subcutaneous bleeding, pain when puncturing of the needle, and liquid leakage when removing the needle. The results of this study confirmed the usefulness of thinner and shorter injector needles to alleviate patients' distress, suggesting the necessity of considering their usability of needles during guidance on selfinjection.