- 一般社団法人 日本医療薬学会
- 病院薬学 (ISSN:03899098)
- vol.24, no.5, pp.479-483, 1998-10-10 (Released:2011-08-11)
In order to improve children's compliance in taking bitter medicine, a gel base confectionery, which immediately changes into a jelly from after adding a special liquid, was used to mask the characteristic taste of the medicament. In pre-clinical trials, this jelly was evaluated by six adult volunteers who all reported the bitter taste to distinctly disappear in the jelly-formed quinia compared to a the powder of this medicine. Furthermore, we confirmed no comparable changes to exist in the serum levels of acetaminophene between acetaminophene alone and the gelbasemedicament mixture by oral administration. A clinical trial in three pediatric patients, who usually refuse medication because the bitter taste of the drugs, resulted in a 100% drug compliance for these children.