著者

熊谷 岳文 木平 孝高 藤村 よしの 宮後 憲 片山 千亜季 松谷 望 井上 裕文 鶴田 泰人 吉富 博則 佐藤 英治

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.140, no.4, pp.577-584, 2020-04-01 (Released:2020-04-01)

参考文献数

12

被引用文献数

1 2

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Elneopa NF No. 1 and No. 2 infusions are complete parenteral nutrition solutions packaged as four-chambered bags. They have been used for home parenteral nutrition, with insulin injected into the bags for patients whose blood glucose becomes elevated. In this study, the stability of insulin in No. 1 and No. 2 bags was investigated. The quantity of insulin in Elneopa NF No. 2 was significantly lower than that in Elneopa NF No. 1. When insulin was injected into the upper chamber of either product, decreases in insulin levels were not observed. In contrast, the levels of insulin injected into the lower chamber of both products significantly decreased, with a larger difference in Elneopa NF No. 2. As the amino acid content is different between No. 1 and No. 2, amino acids may be considered a potential cause for the degradation of insulin in the bags. In addition, decreases in insulin levels were observed as the solutions passed through infusion sets just after flushing began, with both Elneopa NF No. 1 and No. 2. In conclusion, the concentration of insulin injected into the Elneopa infusion bags decreases, especially in No. 2 bags, and insulin is absorbed by the infusion sets.

著者

熊谷 岳文 楢原 菜穂子 佐藤 英治 木平 孝高 藤村 よしの 小嶋 英二朗 小川 祥二郎 伊達 有子 鶴田 泰人 吉富 博則 井上 裕文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.4, pp.599-610, 2021-04-01 (Released:2021-04-01)

参考文献数

14

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Elneopa NF No. 1 and No. 2 infusions are total parenteral nutrition solutions packaged in four-chambered infusion bags. They have been used as home parenteral nutrition, with various drugs injected into the infusion bags, for treating patient symptoms. In this study, we investigated the stability of six drugs, including famotidine, scopolamine butylbromide, furosemide, bromhexine hydrochloride, betamethasone sodium phosphate, and metoclopramide hydrochloride in the infusion bags under dark conditions at 4℃ for 7 days. Additionally, we developed a high-performance liquid chromatography method to determine drug concentrations in the infusions. The concentrations of injected famotidine, scopolamine butylbromide, and betamethasone sodium phosphate remained unchanged when the four chambers of Elneopa NF No. 1 and No. 2 were opened and the infusions were mixed. Their respective concentrations in the upper and lower chambers also remained unchanged. The concentration of furosemide in the upper chamber of the No. 1 infusion bag decreased after 5 days, although no change was observed in the other chambers and the mixed infusions with the four chambers opened. The concentration of bromhexine hydrochloride slightly decreased in the upper chambers (approximately 3%) after the co-infusion but decreased significantly in the other chambers and the mixed infusions with the four chambers opened. The concentration of metoclopramide hydrochloride significantly decreased in the upper chambers after the co-infusion; however, no change in concentration was observed in the other chambers and the mixed infusion with the four chambers opened. The results of this study provide useful information on home-based parenteral nutrition.

著者

下村 麻衣子 松重 武志 井上 裕文

出版者

日本小児医事出版社

雑誌

小児科臨床 (ISSN:0021518X)

巻号頁・発行日

vol.64, no.7, pp.1699-1702, 2011-07

被引用文献数

1

著者

高田 宗一朗 井上 裕文 篠田 茂樹

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

vol.84, no.861, pp.17-00522-17-00522, 2018 (Released:2018-05-25)

参考文献数

20

被引用文献数

2

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In this paper, deterioration diagnosis for distribution main pipe was studied using the uniform cylindrical shell approximation and in-plane bending mode. The in-plane bending mode is expected to have high accuracy in detection of deterioration, because the eigen frecuency of the mode is proportional to pipe thickness. First, using the finite element method, the characteristics of in-plane bending mode are investigated. It is confirmed that in-plane bending mode has little small dependence on the pipe length and the boundary conditions at the pipe ends, it appears in the audio frequency bands, and it has linear dependence on the pipe thickness. In addition, formula with two dimensional ring approximation is derived. Moreover, the average thickness and the uniform-cylindrical shell approximation are introduced for deal with the deteriorated pipe. Using the thinning pipe thickness of previous study, validity of the average thickness and the uniform-cylindrical shell approximation were confirmed. On the other hand, actual pipeline has the sub-structure, for example, valve, hydrant, and so on. In order to deal with the coupled vibration between the cylindrical shell and the sub-structure, eigenvalue analysis are conducted using the Semi-Analytical Receptance Method (SARM). The experimental consideration were conducted in case of that the sub-structure non-attached case. The in-plane bending mode is observed experimentally on the actual pipe system and its resonant frequency shows good match with the theoretical values.