著者

別府 秀彦 渡邊 治夫

出版者

Osaka Urban Living and Health Association

雑誌

生活衛生 (ISSN:05824176)

巻号頁・発行日

vol.55, no.1, pp.3-14, 2011-03-10 (Released:2011-03-18)

参考文献数

20

被引用文献数

2

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Human clinical studies have yielded a great number of findings on the suppressive effect of indigestible dextrin on glucose absorption. The suppressive effect tends to be marked in subject groups whose blood glucose is at high levels in blood tests and the degree of suppression may vary depending on the saccharide species used for loading. The following is a summary review of the suppressive effect of indigestible dextrin as reported in scientific papers.1) In starch loading tests, although a significant difference in the degree of blood glucose suppression by indigestible dextrin is seen in groups whose blood glucose values after placebo ingestion are higher than average, no such difference is commonly observed in low-value groups.2) When groups with high and low blood glucose values before testing are classified in the same starch loading study, however, a significant difference is observed even in low-value groups, as the low-value group includes subjects in the placebo group with higher blood glucose values showing higher peak values at testing.3) In sucrose loading tests, the significant difference was observed more clearly not only in high-value groups but also in low-value groups. Since the inhibitory action of indigestible dextrin is strong on α-glucosidase when it binds to sucrose in order to hydrolyze into glucose and fructose, it appears certain that suppression of glucose absorption into the blood takes place.4) When maltose loading was carried out in twelve healthy young subjects (mean age: 21.4±0.51) in a preliminary study, there was a significant difference in the degree of blood glucose suppression in the groups with higher than average blood glucose level. However, no significant difference was found in another test, in which maltose was loaded to 13 adult subjects (mean age: 54.4±5.5). Although the glucose absorption at maltose hydrolysis in α-glucosidase reaction may be inhibited by indigestible dextrin like as that at starch hydrolysis, the results of the maltose loading test were varied.5) Since α-glucosidase is distributed over the small intestine wall, in order to inhibit co-transportation of the glucose into the blood in the hydrolysis of disaccharide by α-glucosidase, it is necessary for indigestible dextrin to also be distributed quickly over the same small intestine wall. If the loaded foods are taken in slowly, blood glucose level will describe a gradually increasing curve over time; similarly, if indigestible dextrin is taken in slowly, the distribution of the indigestible dextrin to the intestinal wall will be slow and inefficient for inhibition of glucose absorption.

著者

井上 孝 伊藤 哲也 別府 秀彦

出版者

食品新素材協議会

雑誌

日本食品新素材研究会誌 (ISSN:13448935)

巻号頁・発行日

vol.8, no.2, pp.145-154, 2005