著者

前田 康博

出版者

日本政治学会

雑誌

年報政治学 (ISSN:05494192)

巻号頁・発行日

vol.27, pp.183-201,en8, 1977-03-31 (Released:2009-12-21)

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Comparative-primatologically, Gestalt of human society has the methodological indeterminacy, because of his peculiar anthropological ενεργεια-dominating-δυναμιζ-complex: Political Integration in the development.Political Integration is one thing, Social Integration is the other: the latter is naturally given due to each bio-behavioral characteristics of each genus; the former, to be artificially and specific anthropologically produced through the mutually intermediating formation of both social productivity and Dominance-Subjugation category.The Relationship of Dominance-Subjugation is, however commonplace it may seem, the organizational-historical category sui generis of human society, the uncritically generalized application allover non-human spheres of which is quite anthropomorphological error.But, Dominance must be institutionalized, logically: because of the necessity of feed-back for its own survival, and socio-physically: because of the socio-physical υλη of Dis-Communicative Cybernetical Control of Dominance itself. In fact, the social possibility of political resistance depends upon the socio-physical reality of dis-communicative resistance effect.Behavioral-functionally speaking, any kind of social activity is, in each way, some Dis-Communicative Cybernetical Control Matrix, formed and developed with and in the formation and development of the organizational-historical category of Dominance-Subjugation.Now, the optimal control of Dis-Communicative Cybernetics at the optimal Dis-Communicative degree is to be achieved, not so much positivistically, as dialectically: neither verifiable nor falsifiable, but only shifting the responsibility of verification to another.Accordingly, the production of the social values in Dis-Communicative Cybernetical Control Matrix cannot help dialectically transforming itself into the production of the social non-values as well, accompanied and emphasized by the constant possibility of shifting the responsibilities, which is never seen in non-human society upon Social Integration only.Nevertheless or just therefore, Political Integration as the condition of the possiblity, of human society, neither yet completely established nor yet sufficiently evolved even in such form as modern sovereign state, is the most fundamental political problem.Behaviorism, taking Political Integration for granted too much, has been concerned only with ενεργεια of human society, which remains methodologically to be analyzed in the framework of ενεργεια-dominating-δυναμιζ-complex.

著者

木村 和哲 前田 康博 堀田 祐志 佐々木 昌一 片岡 智哉

出版者

名古屋市立大学

雑誌

基盤研究(C)

巻号頁・発行日

2013-04-01

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2005年に男性型脱毛症治療薬のフィナステリド、2009年に前立腺肥大症治療薬のデュタステリドが承認された。これらの薬剤は5α還元酵素を阻害する薬剤であり、これまでの報告によると5α還元酵素阻害剤服用患者で勃起障害(ED)の副作用が見られたことを報告されている。EDと同様の機序で動脈硬化が進行することが知られており、本研究では5α還元酵素阻害剤による心血管機能への副作用を検討した。ラットにデュタステリドを連日投与したところ、4週後および8週後の時点でEDを発症した。一方、大動脈を用いて血管内皮機能を薬理学的に評価したところいずれの期間においてもデュタステリド投与による変化は観察されなかった。