著者

川上 恵 北田 徳昭 米澤 淳 岡村 みや子 尾崎 淳子 池見 泰明 中川 俊作 今井 哲司 中川 貴之 土井 恵太郎 秋月 修治 武藤 学 寺田 智祐

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.25, no.2, pp.83-90, 2023-08-31 (Released:2023-09-15)

参考文献数

18

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Objective: In patients with specific backgrounds, comprehensive identification of health problems and proactive pharmacist intervention are crucial to providing safe and effective medical care. However, there are insufficient reports on chemotherapy regimen selection and supportive care management in patients taking immunosuppressants. In this study, to circumvent adverse events, pharmacists intervened with a patient administering tacrolimus (TAC) using known information, focusing on multiple factors attributable to the patient in addition to drug interactions.Methods: The patient was a male in their 70s who received palliative chemotherapy for gastric cancer during their dermatomyositis treatment with TAC. Pharmaceutical support for cancer chemotherapy was provided using the following four procedures: (1) Patient information was collected from interviews and electronic medical records to identify patient-specific problems; (2) Basic pharmacological information was collected from tertiary sources, focusing on the interaction between TAC and aprepitant (APR). Furthermore, clinical reports were collected, and the pharmacokinetic drug interaction significance classification system was used for quantitative predictions; (3) The information obtained in steps 1) and 2) was evaluated, and comprehensive proposals linked to the patient information were presented; (4) Adverse events, TAC blood level, and patient outcomes were monitored after treatment initiation.Results: A chemotherapy regimen consisting of S-1/oxaliplatin therapy without APR was selected. The adverse effects were controllable, and the treatment was completed without many adverse events. Meanwhile, TAC adherence was unaffected by cancer chemotherapy, and the TAC blood concentration or dose ratios were controlled within the same range as previously reported.Conclusion: In cancer chemotherapy, for cases with limited evidence or information, comprehensive pharmaceutical support was provided using known patient information, considering multiple patient factors. This report is beneficial as an example of supportive care management by a pharmacist and contributes to providing optimal service in cases with specific backgrounds.

著者

西山 祐美 北田 徳昭 関戸 聡子 小林 睦 渡 雅克 内田 享弘 松山 賢治 黒田 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.2, pp.184-191, 2002-04-10 (Released:2011-03-04)

参考文献数

10

被引用文献数

4 4

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A four-week practical hospital training course for undergraduates at Takarazuka Municipal Hospital has been conducted since 1998. The curriculum at our hospital consists of three elements, i.e., lectures on hospital pharmacy, the dispensing service and the clinical pharmacy service. Regarding the clinical pharmacy service, a case study had token a long time for the purpose of learning the actual services. In this study, we compared the results of the new curriculum with those of previous curriculums to establish a more effective and practical curriculum for undergraduates. Our curriculum showed no significant difference with the findings of other reports. Next, we investigated the student' s awareness by questionnaire. The results showed that most students developed on increased awareness of the pharmacist' s daily practice by the end of the practical training course. However it also showed a tendency that their interests in pharmacy practice differed according to their future courses and the university they were studying.From these results, further progress therefore appears to still be obtainable by increasing the cooperation between pharmaceutical universities and hospital pharmacies. In addition, it was considered that our curriculum should be further improved by better meeting the needs of students during the practical training course.

著者

北田 徳昭 関戸 聡子 小林 睦 渡 雅克 折山 毅 黒田 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.3, pp.275-281, 2001-06-10 (Released:2011-03-04)

参考文献数

15

被引用文献数

2 2

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In the present study, we implemented the self-monitoring of side effects in surgical outpatients with breast cancer to improve their quality of life (QOL). Self-monitoring of side effects was carried out by entering the early symptoms (myelosuppression and gastrointestinal failures) on a specially prepared side effect checking-sheet.Six outpatients participated in this study. The chemotherapeutic regimens consisted of cyclophosphamide, adriamycin and 5-fluorouracil, i.e. CAF therapy.In these patients, a mild myelosuppression was seen after the completion of half of each protocol (from approximately day 8 to 14). However, there was no relationship between the early symptoms of myelosuppression (“fever”, “general fatigue” and “throat pain” score) and the number of leucocytes. On the other hand, the self-monitoring of side effects showed a better influence on the subjective score for the symptoms of gastrointestinal failures (i.e. “nausea”).In the present study, the self-monitoring of side effects in outpatients with breast cancer was thus suggested to be a useful tool for improving the patient's QOL.

著者

小林 睦 関戸 聡子 北田 徳昭 西山 祐美 吉岡 睦展 辻 隆志 渡 雅克 安藤 厚志 黒田 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.3, pp.262-270, 2001-06-10 (Released:2011-03-04)

参考文献数

5

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We developed a computer program for drug information for patients using File Maker Pro® software package (ver 4.0). This program consists of four databases : 1) a main database which manages data of drug efficacies, the initial symptoms of serious side effects, cautions, drug interactions, 2) standardization for drug efficacies, 3) standardization of the initial symptoms of serious side effects, and 4) information on the package insert for drugs.These four databases enabled pharmacists to provide standardized drug information rapidly not only to patients but also to other medical staff members.Moreover, these four databases connected with a relational function of File Maker Pro® enabled us to automatically update the data on drug efficacies and initial symptoms of serious side effects by in putting the drug code numbers designated by the Ministry of Health Labor and Welfare into this program.These results suggested this program to be useful for the standardization of drug information and the automatic updating of the data.