著者
岡村 信幸 安保 尚美 青野 美和 江口 倫由 吉井 久乃 小野 行雄 八木 晟
出版者
和漢医薬学会
雑誌
和漢医薬学雑誌 (ISSN:13406302)
巻号頁・発行日
vol.19, no.3, pp.114-118, 2002-06-20
被引用文献数
1 1

Daio-kanzo-to is a Kampo medicine for acute and chronic constipation which consists of a combination of rhubarb and glycyrrhiza. The contribution of rhubarb is to provide a purgative effect, due to the presence of sennosides. Sennoside A is known to decompose on heating during decoction. Therefore, it is said that Kampo decoctions containing rhubarb rather do not have to be boiled for a long time when targeting the purgative activity of sennoside A. This study was performed to clarify the relationship between decocting times of rhubarb and purgative activity. The variation of sennoside A content in rhubarb during the decocting times of 5 to 240 min was shown to be almost the same as that of Daio-kanzo-to. Compared to sennoside A content between powder and cut rhubarb during the period of decoction, the time when the maximum dissolution was reached had significant differences (powder: 10 min, cut: 40 min). Each purgative activity of powder and cut rhubarb decoctions was in proportion to sennoside A content. Kampo decoctions are generally prepared with cut crude drugs. Therefore, we concluded that usual decoction (40 min) is most suitable for Kampo medicines containing rhubarb to use for constipation.