著者

野田 敦子 野田 浩司 今村 孝史 小野 行雄 森田 美華 甲斐 麻美子 嶺 佐知子 後藤 茂

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.111, no.9, pp.499-503, 1991-09-25 (Released:2008-05-30)

参考文献数

16

被引用文献数

3 6

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Pentanthrene type heterocyclic compounds, which contain oxazole, isoxazole, oxadiazole, thiazole, isothiazole, thiadiazole or pyrrole ring as C-ring, and naphthalene, quinoline, isoquinoline or quinoxaline ring as A·B-ring, were prepared, and their monoamine oxidase (MAO) inhibitory activities were examined. As expected from our previous investigation on the structure-activity relationship of this series, most of them showed strong inhibitory potency to both MAO-A and MAO-B. However, a few indicated highly selective inhibition for either of MAO subtypes.

著者

下里 俊行 小野 行雄

出版者

上越教育大学

雑誌

上越教育大学研究紀要 (ISSN:09158162)

巻号頁・発行日

vol.23, no.1, pp.205-223, 2003

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本研究は,2002年5月~9月にかけて神奈川県立金沢東高等学校の選択科目「基礎国際文化」において実施されたアフガニスタン・カブール市の高校生との衛星電話・テレビ電話を通した直接対話の授業実践に関して,その経緯と成果について考察し,今後のグローバル教育における新しい通信メディアの活用と国際NGOとの連携の可能性について検討するものである。この新しい試みでは,テレビ電話による画像と音声を通じて,異なる国籍と文化的背景をもった同世代の若者たちが一人ひとり直接対話した。それは,互いに相手を個別具体的な人格として理解することを可能にさせ,いわばグローバルな市民社会のなかでの相互承認と共感とを体験する新たな可能性を切り開いたといえる。同時に,この新しい試みが通常のカリキュラムとして確立・普及するためには解決すべき課題は多い。たとえば衛星回線の使用料負担や対話相手との調整などである。したがって,PTAなど学校内外の諸団体からの支援や国際NGOとの協力がこれらの課題の解決のために不可欠であるが,同時にインターネット利用によるコスト問題の解決の見通しもある。This study examines both the process and result of learning interactions that occurred in a new trial of global education by using "Direct Talking through INMARSAT Satellite Telecommunications Terminals and Video Phone" between high school students of Kabul city Afghanistan and Japan. This new learning method was undertaken as an elective subject "Basic International Culture" in Higashi-Kanazawa High School in Kanagawa prefecture from May to September in 2002. Moreover this study will examine the practical use of the new communication media and the possibility of connection with transnational NGO for a global education in the future. With this experiment, those young people who have different nationalities and cultural backgrounds could talk each other through this satellite telecommunications terminals and video phone directly. The experiment proved successful for the two parties such that they succeeded in understanding each other as individual concrete characters. And it may be said that this new technique of telecommunications creates some possibilities to experience a new mutual approach in a global civil society. At the same time, many new problems should be resolved so that this new experiment will spread as an established curriculum. For example, there may be a burden of the fee for use of a satellite connection and adjustment for use between other countries. There for, different groups such as PTAs, international exchange associations and some cooperation with transnational NGO's support would be needed for one of the solutions. However, we can point out that there may be some other prospective solutions in which using the videophone proves effective and practical.

著者

岡村 信幸 安保 尚美 青野 美和 江口 倫由 吉井 久乃 小野 行雄 八木 晟

出版者

和漢医薬学会

雑誌

和漢医薬学雑誌 (ISSN:13406302)

巻号頁・発行日

vol.19, no.3, pp.114-118, 2002-06-20

被引用文献数

1 1

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Daio-kanzo-to is a Kampo medicine for acute and chronic constipation which consists of a combination of rhubarb and glycyrrhiza. The contribution of rhubarb is to provide a purgative effect, due to the presence of sennosides. Sennoside A is known to decompose on heating during decoction. Therefore, it is said that Kampo decoctions containing rhubarb rather do not have to be boiled for a long time when targeting the purgative activity of sennoside A. This study was performed to clarify the relationship between decocting times of rhubarb and purgative activity. The variation of sennoside A content in rhubarb during the decocting times of 5 to 240 min was shown to be almost the same as that of Daio-kanzo-to. Compared to sennoside A content between powder and cut rhubarb during the period of decoction, the time when the maximum dissolution was reached had significant differences (powder: 10 min, cut: 40 min). Each purgative activity of powder and cut rhubarb decoctions was in proportion to sennoside A content. Kampo decoctions are generally prepared with cut crude drugs. Therefore, we concluded that usual decoction (40 min) is most suitable for Kampo medicines containing rhubarb to use for constipation.

著者

秦 季之 堀井 梢 松島 裕貴 廣瀬 順造 小野 行雄 佐藤 英治 吉富 博則

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.6, pp.691-701, 2013 (Released:2013-06-01)

参考文献数

30

被引用文献数

3 7

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The text mining and full-text searching function were used to analyze the digitalized daily reports of the practical training in pharmacology submitted to the web system in Fukuyama University. Collocations connected to the word “inspection” were searched in the daily reports using the text mining and the full-text search functions of the system. Many collocation groups connected to “inspection” were found in the daily reports and the greatest number of collocations was associated with “preparation of drugs”. Practical training in narcotic dispensing has two different aspects: inspection and experience training. The number of people who reported a relation between “inspection” and “narcotics dispensing” in the daily reports was very similar to those who reported a connection between “experience” and “narcotics”. Practical training to handle narcotic dispensing is the most fundamental training that the pharmacist must undertake. The progression of team-based medical care has caused medical personnel to recognize the practical training in pharmacology, and the number of the people who reported a relation between “inspection” and “team medical care” in 2011 increased in comparison to 2010. Moreover, the progression of cooperation among hospitals, pharmacies, and local blanches of the Japan Pharmaceutical Association is beneficial to practical training. Practical training in pharmacology is based on the core curriculum, but undergoes periodic modification due to societal circumstances. Therefore, these results suggest that the construction of web system for submitting daily reports is useful for analyzing the daily reports.