著者

岡村信幸著

出版者

[岡村信幸]

巻号頁・発行日

1999

著者

岡村 信幸 安保 尚美 青野 美和 江口 倫由 吉井 久乃 小野 行雄 八木 晟

出版者

和漢医薬学会

雑誌

和漢医薬学雑誌 (ISSN:13406302)

巻号頁・発行日

vol.19, no.3, pp.114-118, 2002-06-20

被引用文献数

1 1

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Daio-kanzo-to is a Kampo medicine for acute and chronic constipation which consists of a combination of rhubarb and glycyrrhiza. The contribution of rhubarb is to provide a purgative effect, due to the presence of sennosides. Sennoside A is known to decompose on heating during decoction. Therefore, it is said that Kampo decoctions containing rhubarb rather do not have to be boiled for a long time when targeting the purgative activity of sennoside A. This study was performed to clarify the relationship between decocting times of rhubarb and purgative activity. The variation of sennoside A content in rhubarb during the decocting times of 5 to 240 min was shown to be almost the same as that of Daio-kanzo-to. Compared to sennoside A content between powder and cut rhubarb during the period of decoction, the time when the maximum dissolution was reached had significant differences (powder: 10 min, cut: 40 min). Each purgative activity of powder and cut rhubarb decoctions was in proportion to sennoside A content. Kampo decoctions are generally prepared with cut crude drugs. Therefore, we concluded that usual decoction (40 min) is most suitable for Kampo medicines containing rhubarb to use for constipation.

著者

原口 博行 斉藤 崇 岡村 信幸 八木 晟

出版者

福山大学

雑誌

福山大学薬学部研究年報 (ISSN:0288724X)

巻号頁・発行日

vol.14, 1996