著者

武長 徹也 竹内 聡志 後藤 英之 吉田 雅人 西森 康浩 大塚 隆信 杉本 勝正 大藪 直子 土屋 篤志 多和田 兼章

出版者

日本肩関節学会

雑誌

肩関節 (ISSN:09104461)

巻号頁・発行日

vol.37, no.3, pp.1121-1123, 2009

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<B>Background:</B> The purpose of the present study was to evaluate the clinical results of conservative treatment for rotator cuff tears.<BR><B>Methods:</B> 33 shoulders of 28 patients were evaluated and diagnosed as having rotator cuff tear with magnetic resonance image or ultrasonography in our institution. There were 13 male cases (17 shoulders), and 15 female cases (16 shoulders). The average age of the 33 shoulders at the time of the diagnosis was 70.9 years old (range 56 to 82 years) and their mean follow-up period was 37.5 months (range 12 to 106 months). With respect to tear size, 4 shoulders were categorized as massive tears, 5 were large tears, 14 were medium tears, 9 were small tears. There was 1 partial tear at the bursal side. The clinical results were evaluated by Japanese Orthopaedic Association shoulder scoring system (JOA score) and pre and post therapeutic active range of motion was also investigated.<BR><B>Results:</B> The average JOA score improved from 69.2 points at first exam to 84.0 points at the final follow-up. However, younger patients (less than 60 years old) showed deterioration. Improvement of active range of motion has been confirmed from 139 to 156 degrees in elevation, from 135 to 150 degrees in abduction, from 57 to 63 degrees in external rotation and from L2 to L1 level in internal rotation at the final follow up.<BR><B>Conclusion:</B> In most of the cases, clinical results of conservative treatment for rotator cuff tears were satisfactory except for younger and active patients.

著者

土屋 篤志 大藪 直子 後藤 英之 堀内 統 吉田 雅人 西森 康浩 大塚 隆信 武長 徹也 杉本 勝正

出版者

日本肩関節学会

雑誌

肩関節 (ISSN:09104461)

巻号頁・発行日

vol.35, no.2, pp.567-569, 2011

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We investigated the shoulder function of the frozen shoulder after an average of thirty months (12 to 108 months) of the conservative treatment. In this study, 17 shoulders of 16 patients (13 males and 3 females) of non-traumatic frozen shoulder without rotator cuff tear were investigated. The mean age of all cases was 66 years old, ranging from 47 to 76 years old. At an average of 30 months follow-up, the clinical results and shoulder function including subjective and objective evaluation, range of motion and shoulder strength using micro FET, were investigated. The mean JOA score was 63.7 points at the initial treatment and 82.5 points at the end of the treatment. After thirty months of the treatment, JOA score was improved to 93.4 points. About 88% of the patients were satisfied with their daily living, although 16.7% of the patients changed sports activity level or their work. Seven of 17 patients who were satisfied with their ADL, restricted some concrete action related to shoulder function such as scratching their back. The range of motion of flexion, abduction and external rotation of the affected side tended to be lower compared with the normal side, but not significantly. The strength of the shoulder of the affected side was improved without a significant difference from normal side. The prognosis of the frozen shoulder was relatively good with a little discomfort for living and a limitation of sports activity.

著者

中田 久美子 小野 千紘 吉田 薫 吉田 雅人 吉田 学 山下 直樹

出版者

日本繁殖生物学会

雑誌

日本繁殖生物学会 講演要旨集 第108回日本繁殖生物学会大会

巻号頁・発行日

pp.OR1-11, 2015 (Released:2015-09-15)

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【目的】現在,テオフィリン等の薬剤がヒト不動精子の運動性回復に使用されているが,顕微授精の際に刺入精子とともに卵子細胞内への薬剤が混入することが危惧されている。一方,水素分子は細胞毒性の高い活性酸素種を選択的に還元する作用を有し,副作用が極めて少ないことが知られている。本研究は,解糖系と電子伝達系によるATP産生の阻害剤を用いて,ヒト精子の運動性に対する水素分子の作用機序を明らかにすることを目的とした。 【方法】インフォームドコンセントの得られた,治療後廃棄予定の精子(n=26)を用いた。本実験では85%以上の運動性を有する正常精子を材料とした。その精子をTYB(Test-Yolk-Buffer,JX日鉱日石エネルギー)にて凍結,融解を2回繰り返し,2回目の融解後の洗浄にはグルコース非添加のTYH(G-N区)を使用し,100μlに調整した後,室温に静置した。24時間後,再度遠心処置を行い,ペレットを3等分にし,50μlのグルコース添加のTYH(G+N区),水素分子含有のグルコース非添加のTYH(G-H区)とG-N区にそれぞれ混和した。また,一部のG-N区およびG-H区に40μMのアンチマイシンAを添加した(G-N-A区,G-H-A区)。各過程で,マクラーチャンバーおよびSCAにて運動率および運動性を測定した。 【結果】G-N,G+N,G-H区の運動率はそれぞれ,2.2%,9.7%,8.3%であり,G+N,G-H区はG-N区よりも有意に高かった(P<0.01)。G-N-A区の運動率は0.07%であるのに対し,G-H-A区は1.8%であり,有意に高かった(P<0.05)。 【考察】グルコース非添加かつ電子伝達系阻害剤の存在下で水素分子は,ヒト精子の運動性を有意に改善させた。これらの結果は,水素分子は精子ミトコンドリアの電子伝達系のATP産生を促進する効果があることが示唆している。