著者

山本 郁男 宇佐見 則行 井本 真澄 宇佐見 則行 井本 真澄

出版者

九州保健福祉大学

雑誌

基盤研究(C)

巻号頁・発行日

2008

---

我々は、これまでマリファナ(大麻)の薬理および毒性に関して、三大主成分(カンナビノイド)、THC(tetrahydrocannabinol)、CBD(cannabidiol)、CBN(cannabinol)の代謝を中心に報告してきた。本研究においては、シクロヘキサン環を酸化して芳香環化に関与するCYP19(アロマターゼ)によるTHCの代謝を検討した結果、代謝物の1つが8-ヒドロキシCBNであることを同定した。そこで、CYP19が芳香環化と同時にCBNのヒドロキシル化に関与することを示唆した。一方、CYP19によってTHCとCBDからCBNが形成されることをGC/MS方法によって確証した。さらに、これらのカンナビノイドのステロイド代謝(CYP19と17β-HSD(17β-ヒドロキシステロイド脱水素酵素)によるアンドロステロン(AND)、テストステロン(TES)およびエストロン(E1)の代謝)に及ぼす影響を検討した。その結果、CYP19によってエストラジオール(E2)へのTESの代謝においてTHC、CBDおよびCBN(50μM)が、それぞれ16、60、46%阻害することが判明した。一方、CYP19によるTESのAND、およびE1のE2への代謝は、THC、CBDおよびCBNによってそれぞれ約20%阻害された。したがって、本研究において、カンナビノイドが性ホルモンの代謝に深く関係していることが明らかとなり、内分泌かく乱作用が示唆された。

著者

渡辺 和人 木村 敏行 宇佐見 則行 山本 郁男

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:21863989)

巻号頁・発行日

no.38, pp.37-49, 2014-12-31

---

There are many novels that deal with marijuana as drug novels. Among them, the novel entitled “Kaigo-nyumon” written by Mr. Norio Mob was to win the Akutagawa Award in 2004. A marijuana user appears in the novel. We thought that a part of the novel was written by the author under the influence of marijuana. This review critically analyzes the contents of the novel from a scientific point of view.

著者

渡辺 和人 木村 敏行 宇佐見 則行 山本 郁男

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:21863989)

巻号頁・発行日

no.38, pp.37-49, 2014-12-31

---

There are many novels that deal with marijuana as drug novels. Among them, the novel entitled "Kaigo-nyumon" written by Mr. Norio Mob was to win the Akutagawa Award in 2004. A marijuana user appears in the novel. We thought that a part of the novel was written by the author under the influence of marijuana. This review critically analyzes the contents of the novel from a scientific point of view.

著者

山本 郁男 岩井 勝正 井本 真澄 宇佐見 則行 ヤマモト イクオ イワイ カツマサ イモト マスミ ウサミ ノリユキ Ikuo YAMAMOTO Katsumasa IWAI Masumi IMOTO Noriyuki USAMI

雑誌

九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare

巻号頁・発行日

vol.6, pp.277-285, 2005-03-25

---

The School of Pharmaceutical Sciences, Kyushu University of Health and Welfare located in Nobeoka City, Miyazaki Prefecture wa founded in April, 2003. This place (Nobeoka) wa famous to be called Himuka(Hyuga), an ancient name, since several handred years ago. Himuka is still used in the historical and sightseeing books. However, it was no reasons why the School of Pharmaceutical Sciences did start at this place, Nobeoka. So, we searched all over the place(Himuka) for some people related to Pharmaceuticla Sciences. As results, Kitsumon AKIZUKI(1989-1981) who lived in Nobeoka during Edo period was picked out among several persons. Although he stayed in Nobeoka only for two years, he had done many great things concerned tin the education, medicine, botany, herbalism, philology and political events. Especially, Kitsumon AKIZUKI invited Hika KAKU, a famous herbalist, from Azimu, Usa (Oita prefecture) and let him investigate and herborize the local herbs near Nobeoka. This paper deals with Kitsumon AKIZUKI and his achievement in his life.

著者

山本 郁男 宇佐見 則行 井本 真澄 岸 信行

出版者

九州保健福祉大学

雑誌

九州保健福祉大学研究紀要 (ISSN:13455451)

巻号頁・発行日

vol.8, pp.187-192, 2007-03-25

被引用文献数

1

---

Shouan Watanabe (1613-1699) was one of the most famous men in the history of Hyuga (Nobeoka, Miyazaki). He was a physician during the Edo period, often called the father of medicine in Nobeoka. He was born in Nobeoka and studied both medicine and Jugaku in Kyoto. After his return to Nobeoka, he practiced medicine and opened a private school for young people. Watanabe was ordered by Yasuzumi Arima, then leader of the Nobeoka-Han, to be a teacher for his son, Kiyozumi Arima. Watanabe had over one hundred students. He was not only a physician and teacher, but also a politician. His grave is still in Zenseiji temple in Yamashita-machi, Nobeoka, with writings by Jinsai Ito and Tougai Ito on it. This paper deals with Watanabe himself, the people around him, and the events of his life.