著者
中塚 幹也 安達 美和 佐々木 愛子 野口 聡一 平松 祐司
出版者
日本母性衛生学会
雑誌
母性衛生 (ISSN:03881512)
巻号頁・発行日
vol.46, no.4, pp.543-549, 2006-01
被引用文献数
6

日本の公的医療機関では, 精神神経学会の性同一性障害(GID)治療ガイドラインに従い, ホルモン療法は18歳以上に施行しているが, 年齢制限には検討の余地がある。このため, GID症例自身が, 説明, ホルモン・手術療法を何歳ごろ受けたかったかを調査した。対象はGID症例181名で, FTM症例117名, MTF症例64名であった。FTM症例の初経は12.8±1.6歳, 乳房増大の自覚は12.2±1.7歳であり, MTF症例の変声は13.6±1.7歳, ひげは15.3±2.5歳にみられた。中学生以前に性別違和感の生じた症例に限って検討すると, GIDについて知った年齢は, FTM症例で22.0±6.6歳, MTF症例では27.0±9.8歳であった。FTM症例では, GIDの説明は12.2±4.2歳, ホルモン療法の開始は15.6±4.0歳, SRSは18.2±6.0歳にしてほしかったとしていたが, MTF症例では, いずれも二次性徴の起こる前の各10.7±6.1歳, 12.5±4.0歳, 14.0±7.6歳と早期の治療を希望していた。現在のGID治療ガイドラインの年齢制限の緩和が必要であるが, 学校教育の中でのGIDの概念の解説, 思春期における適切なGID診断システムの確立などが重要となろう。
著者
安達 美和 高橋 知行
出版者
日本法科学技術学会
雑誌
日本法科学技術学会誌 (ISSN:18801323)
巻号頁・発行日
vol.12, no.1, pp.45-51, 2007 (Released:2007-06-27)
参考文献数
7
被引用文献数
2 1

In the case of food adulteration or suicidal swallowing using dishwashing detergents, several extraction methods were evaluated to extract anionic, nonionic and amphoteric surfactants. Six extraction procedures: diatomaceous earth (ChemElut/chloroform or ethyl acetate), ion-pair liquid-liquid extraction (with methylene blue/chloroform), mixed-mode solid-phase extraction (SPEC PLUS DAU, C18 plus cation exchanger), C18-based solid-phase extraction (Sep-Pak Plus C18) and polymer-based reverse phase extraction (Oasis HLB) were tested. Eleven surfactants: fatty acid alkanolamide (AA), alkyl ether sulfate (AES), alkylglycoside (AG), alkylamine oxide (AO), alpha-olefin sulfonate (AOS-C=C), hydroxy-alkane sulfonate (AOS-OH), alkylamide propylbetaine (APB), fatty acid (FAT), alkylhydroxysulfobetaine (HSB), alkylbenzenesulofonate (LAS), and polyoxyethylene alkyl ether (POE), were extracted from spiked water and highest recoveries (91% for AES to 101% for AO) were obtained with Oasis HLB. On the assumption of food adulteration or stomach contents analysis, soy bean paste “miso” soup, yogurt and curry were spiked with dishwashing detergents and extracted using Oasis HLB. Extraction recoveries from these spiked foods were decreased (1% for LAS and FAT from yogurt to 78% for AO from curry) compared to extraction from spiked water. Except extraction of FAT from miso soup, protein precipitation by ethanol prior to Oasis HLB extraction was effective to improve extraction recoveries (67% for AA from yogurt to 101% for AA from miso soup).
著者
安達 美和 高橋 知行
出版者
日本法科学技術学会
雑誌
日本法科学技術学会誌 (ISSN:18801323)
巻号頁・発行日
vol.10, no.2, pp.99-109, 2005 (Released:2007-07-03)
参考文献数
10
被引用文献数
4 3

High-performance liquid chromatography/mass spectrometry (LC/MS) was applied to the forensic discrimination of dishwashing detergents. Each dishwashing detergent, commercialy available in Japan, consists of anionic, nonionic, amphoteric surfactants or a combination of these surfactants. These surfactants were separated on a reversed-phase C18 column with methanol/10 mM ammonium acetate gradient mobile phase and were identified according to their molecular-related ions and retention times. Sixty-three commercial products were analyzed and 1,928 of all possible 1,953 pairs (ca. 99%) were distinguished without using other analytical methods. All of the indistinguishable products (25 pairs) were variation of products from a same manufacture with different fragrance, and/or concentration, and a product of original equipment manufacturer (OEM). These results indicate that LC/MS is a reliable tool for the forensic discrimination of surfactants in dishwashing detergents.