7 0 0 0 OA 口腔・顔面領域での神経因性疼痛発症・維持に伴う神経栄養因子の関与について
本研究では神経因性疼痛の発症機序および治療方法を検討するため、神経因性疼痛を誘発する動物モデルを作成し、神経因性疼痛にたいする各種神経栄養因子(酸化型ガレクチン、血小板由来神経栄養因子(BDNF)、アルテミン)の効果を調べた。坐骨神経結紮により、結紮側(左側)で熱刺激に対する逃避時間の短縮(痛覚過敏)が生じた。結紮部位に神経栄養因子を塗布した群では、生理食塩水(生食)塗布群に比べ熱刺激に対する痛覚過敏の発症(逃避行動時間の短縮)が著しく遅延した。特に、酸化型ガレクチン塗布群では、結紮直後から28 日目にかけて結紮側の逃避行動の延長(鎮痛効果)が観察された。アルテミンおよび血小板由来神経栄養因子(BDNF)塗布群では、痛覚過敏は抑制されたが、酸化型ガレクチンとは異なり鎮痛効果は認められなかった。
6 0 0 0 OA RifampicinのPharmacokineticsに対する食事の影響
- 著者
- 西村 富啓 河野 晴一 倉島 篤行 久保 博昭 小池 勇一
- 出版者
- The Japanese Society of Clinical Pharmacology and Therapeutics
- 雑誌
- 臨床薬理 (ISSN:03881601)
- 巻号頁・発行日
- vol.37, no.6, pp.353-357, 2006-11-30 (Released:2010-06-28)
- 参考文献数
- 23
- 被引用文献数
- 1 1
Rifampicin (RFP) is one of the first-line drugs in the treatment of tuberculosis. Worldwide, the recommended administration of RFP is before breakfast, however it is commonly administered after the meal in Japan. It is known that the absorption of RFP is affected by a meal. Therefore, the effects of meal on the pharmacokinetics of rifampicin were studied in patients with tuberculosis.Ten male patients participated in this study. Five of the ten patients were given three capsules (450mg of RFP) 30 minutes before breakfast. The other five patients were given the same dose of RFP 30 minutes after breakfast. The mean age and weight were 54.6±3.3 years and 53.9±2.7kg in the group before meal and in the after the meal group, 49.8±8.4 years and 53.8±5.0kg, respectively. All the data were expressed as mean±S.D. Blood samples were taken at 0, 2, 4 and 6 hours after capsule administration. RFP concentra tions in serum were analyzed by reversed-phase high performance liquid chromatography and the relevant pharmacokinetic parameters were calculated. Group means were compared by use of nonparametric statis tics.In the group before meal, the peak concentration (Cmax) was significantly higher than that in the group after meal (9.32±0.88μg/mL versus 5.76 ± 1.04 μg/mL, p<0.05) and the AUC was also significantly higher than that in the group after meal (35.83±3.29μg/hr/mL versus 18.63±4.35μg/hr/mL, p<0.05). These results suggest that RFP should be taken 30 minutes before the meal.
2 0 0 0 OA 日本人におけるカフェイン代謝の多型性 遺伝子型について
- 著者
- 橋口 正行 中島 創 堤 喜美子 織部 尚利 小池 勇一 海老原 昭夫
- 出版者
- 一般社団法人 日本臨床薬理学会
- 雑誌
- 臨床薬理 (ISSN:03881601)
- 巻号頁・発行日
- vol.20, no.1, pp.297-298, 1989-03-31 (Released:2011-02-25)
- 参考文献数
- 6