著者

海老原 昭夫

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.18, no.8, pp.711-713, 1982

著者

橋口 正行 中島 創 堤 喜美子 織部 尚利 小池 勇一 海老原 昭夫

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.20, no.1, pp.297-298, 1989-03-31 (Released:2011-02-25)

参考文献数

6

著者

須永 健一郎 熊谷 雄治 原田 和博 大森 正規 海老原 昭夫 藤村 昭夫

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.27, no.1, pp.37-38, 1996-03-31 (Released:2010-06-28)

参考文献数

1

著者

香川 靖雄 西沢 正豊 鈴木 実 宮武 正 浜本 敏郎 後藤 公彦 本永 英治 泉川 寛元 平田 晴男 海老原 昭夫

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.28, no.4, pp.441-453, 1982 (Released:2009-04-28)

参考文献数

33

被引用文献数

164 230

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Japanese are unique among the peoples of developed count-ries in having a high intake of eicosapentaenoic acid (C 20:5) from fresh fish and this may in part contribute to their low incidence of cardiovas-cular diseases. Mass spectroscopic analyses of eicosapolyenoic acids (C 20:3, C 20:4 and C 20:5) were carried out on the serum of aged persons living on Kohama island in Okinawa and known to have the lowest incidence of cardiovascular diseases in Japan. All but 4 of the 77 persons examined (73.94±7.81 years old) led active fishing-farming lives. The total amount of eicosapolyenoic acids in the serum of persons on Kohama island (46.77±7.46 mg/ 100 ml) was higher (p<0.001) than that in people on mainland Japan, owing to the higher intake of fresh fish (147.7g/day). A positive correlation (p<0.01) was found between serum C 20: 5 concentration (6.82+2.54 mg/100 ml) and high density lipoprotein concentration (55.38±13.83 mg/100 ml). In addition, there were positive correlations (p<0.01) between serum C 20: 3 concentration (6.58+1.61 mg/100 ml) and total cholesterol (188.60±32.30 mg/ 100 ml), and triglyceride and skinfold thickness. The blood pressure level (p<0.01), incidence of abnormal ECG (p<0.05), and salt intake (6.2-8.3g/ day) estimated from urinalysis, were all lower than the average figures for Japanese of similar ages. No persons examined showed Q-wave on ECG. The percentage of smokers and drinkers were similar for Kohama island and mainland Japan.