著者

三星 知 山田 仁志 山崎 修治 小林 真理子 上野 和行 長井 一彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.140, no.7, pp.943-947, 2020-07-01 (Released:2020-07-01)

参考文献数

19

被引用文献数

1

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Concomitant therapy with acetaminophen (APAP) and low-dose aspirin is often used in clinical settings; however, it is unclear whether this combination is involved in the progression of chronic kidney disease (CKD). We hypothesized that concomitant therapy with APAP and low-dose aspirin may cause CKD progression. We carried out a retrospective 6-year cohort study that included all patients who received low-dose aspirin from January 2011 to December 2016 at Kaetsu Hospital. Primary outcome was defined as CKD progression at the end of the study compared with baseline. Among the 441 patients treated during the study period, we identified 89 cases of CKD progression. Multivariate regression analysis showed that exposure to APAP>50 g [odds ratio (OR), 2.68, 95% confidence interval (CI), 1.08-6.70], age increase by 1 year (OR, 1.05, 95% CI, 1.02-1.08), and diabetes mellitus (OR, 2.40, 95% CI, 1.41-4.08) had positive associations with CKD progression. Our findings suggested that concomitant therapy with APAP and low-dose aspirin increased the risk of CKD progression. Therefore, we recommend more thorough monitoring of serum creatinine when patients are on such concomitant therapy. Moreover, it is important to advise users of low-dose aspirin to avoid unnecessary use of APAP, in order to reduce the risk of CKD progression.

著者

山田 仁志 Masashi Yamada

雑誌

国際経営・文化研究 = Cross-cultural business and cultural studies (ISSN:13431412)

巻号頁・発行日

vol.21, no.1, pp.73-83, 2016-12-01

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After the Second World War, the financing behavior of Japanese companies, has been the primary means of debt financing. Therefore, the equity ratio of Japanese companies, were in much lower levels. However, the Japanese economy is in a low growth period, it began to change is seen in the financing behavior of companies.This paper, based on the data of Financial Statement Statistics of Corporations, to discuss the changes in the financing behavior of Japanese companies. Since the 1970s, equity ratio of Japanese companies continued to rise. In the paper, it was pointed out the features of the Japanese companies. Also, describe the changes in the capital structure of the company, it has also referred to the change of corporate assets.

著者

佐藤 竜也 長沼 健 根本 潤 福地 開帆 山田 仁志夫

雑誌

研究報告インターネットと運用技術(IOT) (ISSN:21888787)

巻号頁・発行日

vol.2017-IOT-36, no.30, pp.1-8, 2017-02-24

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ブロックチェーン技術は破壊的イノベーションとして,金融をはじめとした様々な分野で実用可能性が検討されはじめている.ブロックチェーン技術はトランザクションシステムへの適用が期待されているが,その実用化に向けてはトランザクション性能を中心とした現在の実力と残課題の把握が必要である.そこで報告者はブロックチェーン基盤のオープンソースソフトウェアプロジェクトである Hyperledger の基盤実装の一つである Fabric について,モニタリングを含めた検証環境を構築し,性能を中心とした評価を行った.さらに,評価結果に基づいて,実用化に向けた技術課題を抽出した.