文献一覧: 小林真理子 (著者)

2 0 0 0 OA Is Concomitant Therapy with Acetaminophen and Low-dose Aspirin a Risk Factor for CKD Progression? A 6-Year Cohort Study

著者: 三星知山田仁志山崎修治小林真理子上野和行長井一彦
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.140, no.7, pp.943-947, 2020-07-01 (Released:2020-07-01)
参考文献数: 19
被引用文献数: 1

Concomitant therapy with acetaminophen (APAP) and low-dose aspirin is often used in clinical settings; however, it is unclear whether this combination is involved in the progression of chronic kidney disease (CKD). We hypothesized that concomitant therapy with APAP and low-dose aspirin may cause CKD progression. We carried out a retrospective 6-year cohort study that included all patients who received low-dose aspirin from January 2011 to December 2016 at Kaetsu Hospital. Primary outcome was defined as CKD progression at the end of the study compared with baseline. Among the 441 patients treated during the study period, we identified 89 cases of CKD progression. Multivariate regression analysis showed that exposure to APAP>50 g [odds ratio (OR), 2.68, 95% confidence interval (CI), 1.08-6.70], age increase by 1 year (OR, 1.05, 95% CI, 1.02-1.08), and diabetes mellitus (OR, 2.40, 95% CI, 1.41-4.08) had positive associations with CKD progression. Our findings suggested that concomitant therapy with APAP and low-dose aspirin increased the risk of CKD progression. Therefore, we recommend more thorough monitoring of serum creatinine when patients are on such concomitant therapy. Moreover, it is important to advise users of low-dose aspirin to avoid unnecessary use of APAP, in order to reduce the risk of CKD progression.

2020-07-03 22:46:48
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2 0 0 0 発達障害と社会的ひきこもり

著者: 近藤直司小林真理子宮沢久江宇留賀正二小宮山さとみ中嶋真人中嶋彩岩崎弘子境泉洋今村亨萩原和子
出版者: 全国障害者問題研究会
雑誌: 障害者問題研究 (ISSN:03884155)
巻号頁・発行日: vol.37, no.1, pp.21-29, 2009-05

近年,青年期におけるひきこもりケースの中に発達障害を背景とするものが少なくないことが明らかになってきており,個々の発達特性や精神・心理状態を踏まえた支援のあり方が問われている.また,ひきこもりに至る以前の予防的な早期支援のあり方を検討することも重要な課題である.本稿では,まず,ひきこもり問題に占める発達障害の割合や,ひきこもり状態にある広汎性発達障害ケースの特徴について述べ,ひきこもりの発現を未然に防ぐことを目的とした予防的早期支援と不登校・ひきこもりケースへの支援における家族支援の要点について検討する.