著者

竹内 敦子 岡野 登志夫 和田 知子 須藤 都 新谷 有美 小林 正

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.65, no.3, pp.121-124, 1991-03-25

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Effect of solar radiation on vitamin D_2 contents in raw and dried Shiitake mushrooms (Lentinus edodes) was investigated. Contents of vitamin D_2 in raw Shiitake cultured in vinylhouses (average : 21 and 14 IU/piece) were generally lower than those cultured outdoors (average : 100 IU/piece). On the other hand, the contents of ergosterol in all the samples were much higher than those of vitamin D_2 (about 9,000〜46,000 times as weight ratio). When gills parts of the samples cultured in a vinylhouse were exposed to sunlight for 1 h or 3 h at a fine day, the contents of vitamin D_2 increased about 3.6 times (average : 76 IU/piece) or 5 times (average : 104 IU/piece) higher than those before radiation (average : 21 IU/piece). The vitamin D_2 contents in raw Shiitake increased according to increase of solar radiation times. When gills parts of dried Shiitake were exposed to sunlight for 1 h or 3 h, the contents of vitamin D_2 increased about 24 times (average 488 IU_piece) or 27 times (average : 548 IU/piece) higher than those before radiation (average : 20 IU/piece). The contents of vitamin D_2 in raw and dried Shiitake exposed on gills part were significantly higher than those in the samples exposed on pileus parts. Since no significant change was observed in the smell, color and taste of Shiitake by solar radiation, exposure to sunlight is an effective method for increase of vitamin D_2 in raw Shiitake mushurooms.

著者

鎌尾 まや 岡野 登志夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.82, no.11, pp.612-614, 2008-11-25 (Released:2017-10-10)

参考文献数

5

著者

岡野 登志夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.94, no.3, pp.143-149, 2020-03-25 (Released:2021-03-31)

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Vitamin D can only be made by sunlight exposure, and must undergo sequential metabolic activations to form its most active metabolite 1α,25(OH) 2D3 before exerting its hormonal actions in a variety of cells and tissues. 1α,25(OH) 2D3 regulates not only calcium and bone metabolism but also cell proliferation/differentiation, immune system and hormone secretion. 1α,25(OH) 2D3 binds to vitamin D receptor (VDR) and subsequent binding of the hormone-receptor complex along with Retinoid X receptor (RXR) to selected DNA sequences in chromosome induces gene expression of vitamin D-dependent proteins (a genomic action). Additionally, 1α,25(OH) 2D3 induces increases in intracellular calcium, transmembrane signaling, alterations in phospholipid metabolism and protein C kinase activity (a non-genomic action). In recent years, vitamin D research has made a remarkable progress. This review article describes recent advances in basic and clinical vitamin D researches.

著者

和田 昭盛 岡野 登志夫

出版者

神戸薬科大学

雑誌

基盤研究(C)

巻号頁・発行日

2011

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レチノイドX受容体は、他の核内受容体とヘテロダイマーを形成し生理機能を発現することより、脂質代謝異常症や糖尿病など様々な疾患とも関連することが知られている。そこで、RXRのリガンドである9-cis-レチノイン酸のアナログ化合物を合成し、ヘテロダイマーの作用分離が可能なリガンド分子の開発を検討した。その結果、レチノイン酸の疎水性ユニットであるシクロヘキセン部と続く二重結合を(-)-メントンとベンゼン環で縮環した誘導体MentPhMe及びMentPhEtにおいて、それぞれヘテロダイマーであるPPARγ/RXαおよびRLXRα/RXRαに対する選択性を示す化合物を見出すことができた。