1 0 0 0 植物成分の抽出に関する研究 その5 : メギからのベルベリン抽出
- 著者
- 川島 嘉明
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.89, no.10, pp.1386-1391, 1969
Berberine was extracted from slices of Berberis thunbergii, cut into various sizes (#1-#4), with water and methanol at 37°. Results of analysis of extraction rate, indicated that the mechanism of extraction consists of washing, diffusion, and capillary extraction, and mass transfer coefficients for each mechanism were determined. Comparing with the extraction of berberine from the cortex of phellodendron, <SUP>3)</SUP> mass transfer coefficients were distinctly larger.
1 0 0 0 IR <研究論文抄録>テオフィリンナトリウム1水和物の球形晶析法の速度論的研究
1 0 0 0 OA 新しい液中の粒子の凝集現象による晶析造粒法の開発と粒子設計
- 著者
- 川島 嘉明
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.106, no.6, pp.433-445, 1986-06-25 (Released:2011-01-31)
- 参考文献数
- 34
- 被引用文献数
- 1
A novel agglomerated crystallization technique, termed spherical crystallization technique, which can transform fine crystals precipitated into spherical agglomerates in one step during the crystallization process, has been developed by using new agglomeration phenomena of particles in liquid system. In this technique, a binary or a ternary mixture of partially miscible solvents was used as a crystallization solvent. It was found that by choosing the proper proportion of the mixture, a small amount of immiscible liquid was liberated from the system, which could preferentially wet the crystals, forming spherical agglomerates. By using this technique, needle like crystals of salicylic acid were agglomerated into spheres being directly compressible into tablet. Spherically agglomerated crystals of aminophylline were prepared directly by reacting theophylline with ethylenediamine in an alcohol-organic solvent-water mixture. The spherically agglomerated crystals of new complex of indomethacin and epirizole with increased solubilities were prepared. Controlled release microspheres of ibuprofen with acrylic polymer were prepared to improve bioavailability.
- 著者
- 竹内 洋文 半田 哲郎 川島 嘉明
- 出版者
- 一般社団法人 粉体工学会
- 雑誌
- 粉体工学会誌 (ISSN:03866157)
- 巻号頁・発行日
- vol.23, no.8, pp.599-606, 1986-08-10 (Released:2010-04-30)
- 参考文献数
- 24
- 被引用文献数
- 1
1 0 0 0 植物成分の抽出に関する研究-5-メギからのベルベリン抽出
- 著者
- 川島 嘉明
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 薬学雑誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.89, no.10, pp.1386-1391, 1969-10
Berberine was extracted from slices of Berberis thunbergii, cut into various sizes (#1-#4), with water and methanol at 37°. Results of analysis of extraction rate, indicated that the mechanism of extraction consists of washing, diffusion, and capillary extraction, and mass transfer coefficients for each mechanism were determined. Comparing with the extraction of berberine from the cortex of phellodendron, ^<3)> mass transfer coefficients were distinctly larger.
1 0 0 0 OA 植物成分の抽出に関する研究 その4 : ホミカからのストリキニーネおよびブルシン抽出
- 著者
- 岡田 寿太郎 川島 嘉明
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.89, no.10, pp.1345-1351, 1969-10-25
Strychnine and brucine were extracted from slices of strychni seeds, cut into various sizes (#1-#4), in water at 27,37,and 47°. Results of analysis of extraction rate showed that the mechanism of extraction consists of washing, diffusion, and capillary extraction, but the capillary extraction occupies a small part. Mass transfer coefficients of these three mechanisms, which depend distinctly on temperature of the solvent, were determined.