- 著者
- 山崎 晴美 橋本 光二 後藤 實 西山 實
- 雑誌
- 日本歯科医学教育学会雑誌 = Journal of Japanese Association for Dental Education (ISSN:09145133)
- 巻号頁・発行日
- vol.15, no.2, pp.216-229, 2000-03-20
- 被引用文献数
- 2
1 0 0 0 OA 有用天然物成分の研究 第17報
- 著者
- 後藤 實 野口 友昭 渡邊 武
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.78, no.5, pp.464-467, 1958-05-25 (Released:2010-02-19)
- 参考文献数
- 9
- 被引用文献数
- 2 7
Crude drugs and plants, numbering 229 kinds, were examined for principles having uterus contracting action and it was found that an extract of Lespedeza bicolor var. iaponica NAKAI (family Leguminosae) showed a comparatively strong action. From the result of various tests, the active principle of this plant was assumed to be an alkaloid and the principle was extracted y the usual method, affording white prisms melting at 47-48°. A molecular formula of C12H16N2 was given for this substance from elemental analyticalvalues and molecular weight determination. There has been no report of identification of this kind of a substance fro the Lespedeza sp. and the substance was tentatively named alkaloid L.Ultraviolet absorption spectrum and various tests indicated the alkaloid L to possess an indole ring and a side chain of dimethylaminoethyl group was assumed to be attached to its 3-position. The alkaloid L was therefore derived to its methiodide and it was found that this methiodide was identical with N, N-dimethyltryptamine methiodide in respect to its melting point, elemental analyses, and infrared absorption spctrum. Therefore, the alkaloid L would be N, N-dimethyltryptamine. A dose of 50mγ/cc. of this alkaloid contracted excised uterus of a hamster. The effect of N, N-dimethyltryptamine on the tryptophan demand of Lactobacillus arabinosus, with tryptophan as the essential growth factor, was examined by microbiological assay but no effect was found to be exerted on fungal growth.