2 0 0 0 OA 医薬品のレギュラトリーサイエンス
- 著者
- 戸塚 裕一
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- ファルマシア (ISSN:00148601)
- 巻号頁・発行日
- vol.50, no.5, pp.496_2, 2014 (Released:2016-06-21)
1 0 0 0 OA 種々の特性を有するショ糖脂肪酸エステルの滑沢剤としての有用性評価
- 著者
- 山本 ひとみ 戸塚 裕一 内田 実 竹内 洋文
- 出版者
- The Society of Powder Technology, Japan
- 雑誌
- 粉体工学会誌 (ISSN:03866157)
- 巻号頁・発行日
- vol.47, no.6, pp.388-393, 2010-06-10 (Released:2010-06-15)
- 参考文献数
- 7
- 被引用文献数
- 1 3
The lubricant property of sucrose esters of fatty acids (SEs) having different particle size and Hydrophile-Lipophile Balance (HLB) was evaluated with a model formulation in tableting. The binding tendency of the model formulation composed of isomalt powder was depressed by adding SEs in the formulation. Tablets containing SE showed faster disintegration time compared to those containing magnesium stearate or calcium stearate, while the tablets containing SEs indicated a high tensile strength. Milled SE (S-370F) exhibited better tablet properties than original SE (S-370). The SEs having different HLB showed different effects on the resultant tablet properties such as the magnitude of tensile strength, disintegration time, and spreading properties. The relatively hydrophilic SE was found to much improve the resultant disintegrating properties of tablet compared to magnesium stearate, calcium stearate and hydrophobic SEs. Consequently, SEs are able to use as lubricants on tablet formulation by appropriately controlling its particle size, content, and HLB.