8 0 0 0 OA 脳静脈洞血栓症
- 著者
- 新堂 晃大 和田 英夫 冨本 秀和
- 出版者
- 一般社団法人 日本血栓止血学会
- 雑誌
- 日本血栓止血学会誌 (ISSN:09157441)
- 巻号頁・発行日
- vol.25, no.3, pp.399-403, 2014 (Released:2014-07-01)
- 参考文献数
- 21
- 被引用文献数
- 2 2
1 0 0 0 OA Kelch–like protein–11傍腫瘍性神経症候群の診断と治療
- 著者
- 石川 英洋 新堂 晃大 冨本 秀和
- 出版者
- 日本神経治療学会
- 雑誌
- 神経治療学 (ISSN:09168443)
- 巻号頁・発行日
- vol.39, no.3, pp.346-349, 2022 (Released:2022-11-22)
- 参考文献数
- 14
Kelch–like protein 11 (KLHL11)–associated paraneoplastic syndrome (PNS) has been newly categorized as PNS. The corresponding syndromes are cerebellar and/or brainstem involvement, and in the fewer cases, limbic encephalitis. Hearing loss or tinnitus often precedes other symptoms. Findings of cerebrospinal fluid show inflammatory (protein 50mg/dL or greater and leukocyte counts exceeding 5 cells/µL) with oligoclonal bands in over 80% cases. The most common associated tumor is testicular germ cell tumor, especially seminoma. The primary testicular tumor is often spontaneously regressed with or without metastasis in lymph nodes, called a burned–out testicular tumor. Ultrasonography of testis is useful for such cases because it can detect the suggestive findings of burned–out tumors such as fibrosis and microlithiasis as hypoechoic area. The principles for management are treatment of underlying cancer and immunotherapy. KLHL11–PNS may have a more refractory course than PNS associated with antibodies against neural cell surface antigens since KLHL11 antibodies are targeting intracellular autoantigens and cause cytotoxic T–cell–mediated pathogenesis. A recent paper published by Autoimmune Encephalitis Alliance Clinicians Network recommends that tumor treatment and intravenous methylprednisolone followed by short oral taper should be performed as first–line therapy. If there is no improvement cyclophosphamide can be the next option. Then experimental therapy like IL–6 inhibitor or bortezomib can be considered in non–responded cases.
1 0 0 0 退職校長・教頭を対象とした軽度認知障害の評価法
目的:知的職業に従事していた健常者と軽度認知障害(MCI)例の認知機能検査と画像所見について検討する。対象:70歳以上の小中学校校長・教頭退職者9名(男2名、女7名)。方法:全対象者にMini Mental State Examination(MMSE)、レーブン色彩マトリシス検査(RCPM) 、Wisconsin Card Sorting Test(WCST)、リバーミード行動記憶検査(RBMT)を施行した。結果・結論:健常8名ではMMSE、WCSTとRBMTは一般に用いられる平均値と差はなかったが、RCPMが1SDを超える高得点であった。MCIと診断した1名ではRBMTが健常者の平均より3SD以上、また一般平均と比較しても3SD以上低下していた。脳血流シンチでは前頭葉と頭頂葉に血流低下を認めた。