著者

梶田 悦子 伊木 雅之 飛田 芳江 三田村 純枝 日下 幸則 緒方 昭 寺本 路夫 土田 千賀 山本 和高 石井 靖

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.50, no.4, pp.893-900, 1995-10-15 (Released:2009-02-17)

参考文献数

41

被引用文献数

11 9

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We recruited community-dwelling women for participation in a study to investigate the effects of risk factors in lifestyle on bone mineral density (BMD). The subjects were 177 women aged 35 years and over living in a rural area in Fukui Prefecture. Their BMD of the lumbar spine (L2-L4) was determined by dual energy X-ray absorptiometry (DXA). In addition to measurements of height, body weight and grip strength, the lifestyles of the women, including physical load in work, sporting activities, smoking habits, calcium intake, and history of bone fracture were interviewed in detail.Adjusted for age, the BMD significantly correlated to body weight (r=0.337, p<0.05 for premenopausal women and r=0.289, p<0.01 for postmenopausal women) and body mass index (kg/m2) (r=0.291, p<0.05 for premenopausal women and r=0.190, p<0.05 for postmenopausal women). These results indicated the lower body weight to be a risk factor for the osteoporotic process in middle-aged and aged women. With respect to the grip strength as a physical fitness indicator, a significant correlation coefficient (r=0.267, p<0.01) with BMD was obtained for postmenopausal women independent of age and body weight.In univariate analysis, BMD showed no significant correlations with sporting activities, smoking habits, lower back pain and history of bone fracture for either premenopausal women or postmenopausal women. In multiple regression analysis using age, calcium intake, physical load in work, body weight, grip strength, and sporting activities, the latter three variables had significantly increasing effects on BMD, while aging and menopause had significantly negative effects on BMD.Thus, physical excercise was suggested to protect middle-aged and aged women from the osteoporotic process, probably through either maintaining or enhancing muscle strength.

著者

西野 治身 田中 朋子 土肥 祥子 伊木 雅之 梶田 悦子 日下 幸則 鏡森 定信

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.49, no.4, pp.807-815, 1994-10-15 (Released:2009-02-17)

参考文献数

30

被引用文献数

4 2

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Bone mineral density of the lumbar spine (BMD) and biochemical markers for bone turnover were examined to study the mechanisms of age-related and menopause-related bone loss. We measured BMD of the lumbar spine and serum bone alkaline phosphatase (B-AlP) and bone gla-protein (BGP) as markers of bone formation and fasting urinary creatinine-adjusted hydroxyproline (Hyp/Cr) and calcium (Ca/Cr) as those of bone resorption in 166 community-dwelling Japanese women.A highly significant positive correlation between age and each of the biochemical markers, except for Ca/Cr, was observed. This relationship was not linear. Marked elevation in the levels of the markers was found in women in their sixth decade women compared with those in their fifth.All the markers correlated inversely with the BMD and these relationships remained significant after elimination of the effect of age by partialization. When analyzing the subjects in each five-year age group, the positive correlation of Hyp/Cr with Ca/Cr was significant in the subjects aged 45 to 49 and the negative correlation of Hyp/Cr with BMD was significant in those aged 50 to 54. B-AlP correlated positively with BGP in the subjects aged between 50 and 54 and inversely with BMD in those aged between 55 and 59. These correlations were significant. Thus, intercorrelations between the markers were observed five years earlier than were correlations between the markers and BMD. Such associations appeared earlier in terms of the markers for bone resorption than in terms of the markers for bone formation.In the subjects aged 50 to 54 who had encountered menopause more than three years previously, BGP and Hyp/Cr were elevated compared with those in the premenopausal women of similar age and a significant correlation between Hyp/Cr and BMD was observed. Therefore, menopause seemed to account for the uncoupled activation in the bone metabolism found in the subjects around 50 years of age.The decrease in bone mass observed in our subjects around 50 years of age as a result of uncoupling of bone formation and resorption was suggested to be initiated by activation of bone resorption caused by menopause preceding activation of bone formation.