著者

西野 治身 田中 朋子 土肥 祥子 伊木 雅之 梶田 悦子 日下 幸則 鏡森 定信

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.49, no.4, pp.807-815, 1994-10-15 (Released:2009-02-17)

参考文献数

30

被引用文献数

4 2

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Bone mineral density of the lumbar spine (BMD) and biochemical markers for bone turnover were examined to study the mechanisms of age-related and menopause-related bone loss. We measured BMD of the lumbar spine and serum bone alkaline phosphatase (B-AlP) and bone gla-protein (BGP) as markers of bone formation and fasting urinary creatinine-adjusted hydroxyproline (Hyp/Cr) and calcium (Ca/Cr) as those of bone resorption in 166 community-dwelling Japanese women.A highly significant positive correlation between age and each of the biochemical markers, except for Ca/Cr, was observed. This relationship was not linear. Marked elevation in the levels of the markers was found in women in their sixth decade women compared with those in their fifth.All the markers correlated inversely with the BMD and these relationships remained significant after elimination of the effect of age by partialization. When analyzing the subjects in each five-year age group, the positive correlation of Hyp/Cr with Ca/Cr was significant in the subjects aged 45 to 49 and the negative correlation of Hyp/Cr with BMD was significant in those aged 50 to 54. B-AlP correlated positively with BGP in the subjects aged between 50 and 54 and inversely with BMD in those aged between 55 and 59. These correlations were significant. Thus, intercorrelations between the markers were observed five years earlier than were correlations between the markers and BMD. Such associations appeared earlier in terms of the markers for bone resorption than in terms of the markers for bone formation.In the subjects aged 50 to 54 who had encountered menopause more than three years previously, BGP and Hyp/Cr were elevated compared with those in the premenopausal women of similar age and a significant correlation between Hyp/Cr and BMD was observed. Therefore, menopause seemed to account for the uncoupled activation in the bone metabolism found in the subjects around 50 years of age.The decrease in bone mass observed in our subjects around 50 years of age as a result of uncoupling of bone formation and resorption was suggested to be initiated by activation of bone resorption caused by menopause preceding activation of bone formation.

著者

川野 貴弘 西浦 公章 車谷 典男 土肥 祥子 米増 國雄 金内 雅夫 土肥 和紘

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.40, no.10, pp.659-663, 1997-10-30 (Released:2011-03-02)

参考文献数

11

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糖尿病患者は非糖尿病患者に比して大腸癌に罹患しやすいかを検討する目的で横断研究を実施した. 対象は, 総合病院町立大淀病院で全大腸内視鏡検査が施行された患者391例 (男性235例, 女性156例, 平均年齢61歳) である. Mantel-Haenszel法で算出したオッズ比から糖尿病と大腸癌合併の関連性について検討した. 大腸癌の合併は, 糖尿病患者57例中17例 (有病率30%) に対し, 非糖尿病患者334例中48例 (有病率14%) であった. 大腸癌有病率についての非糖尿病群に対する糖尿病群のオッズ比は, 2.35 (95%信頼区間: 1.28~4.48) であった. 以上から, 糖尿病患者は, 非糖尿病患者に比して大腸癌に罹患しやすいことが示唆される.