著者

中本 恵理 川上 和宜 今田 洋司 式部 さあ里 杉田 一男 篠崎 英司 末永 光邦 松阪 諭 水沼 信之 濱 敏弘

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.7, pp.403-409, 2011 (Released:2012-08-30)

参考文献数

16

被引用文献数

1 3

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Cetuximab, a therapeutic agent for metastatic colorectal cancer, is a chimeric monoclonal antibody that binds and inhibits the epidermal growth factor receptor (EGFR). Adverse events associated with cetuximab include skin disorders, which occur at a high incidence, infusion reactions, and electrolyte disorders, such as hypomagnesemia. The incidence and time of onset of hypomagnesemia following the start of cetuximab treatment were investigated retrospectively. The efficacy of oral magnesium preparations in preventing hypomagnesemia was also examined.At The Cancer Institute Hospital of Japanese Foundation For Cancer Research, the incidence of hypomagnesemia in patients treated with cetuximab was 39.3%. However, there was no clear trend in the time of onset. In addition, there was no difference in the incidence of hypomagnesemia as a function of whether oral magnesium preparations were administered (p=0.097). Some patients developed severe hypomagnesemia and an intravenous magnesium preparation was not very effective in bringing about recovery, necessitating discontinuation of cetuximab therapy.Mild hypomagnesemia may be overlooked because subjective symptoms are not readily apparent. However, if it worsens, hypomagnesemia may lead to serious adverse events, such as arrhythmias, which would require discontinuation of cetuximab treatment. In pa tients receiving cetuximab, therefore, serum magnesium levels must be monitored regularly since early detection and treatment of hypomagnesemia are very important.

著者

水沼 信 中村 安弘 中園 眞人

出版者

日本建築学会

雑誌

日本建築学会環境系論文集 (ISSN:13480685)

巻号頁・発行日

vol.72, no.616, pp.37-43, 2007-06-30 (Released:2017-02-25)

参考文献数

34

被引用文献数

3 3

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The purpose of this study is to develop the ECO-insulator, which has thermal, humidity control and fireproof performance, for another to utilize agricultural wastes: rice-straw and chaff. Firstly, material properties of this ECO-insulator were measured and next, numerical simulations using these material properties were performed and the results of this ECO-insulator were compared with cases of Glass Wool and Extruded Polystyrene. The results are as follows; 1) Thermal performance of the insulator was more than one of Giass Wool 10K. 2) The fireproof performance was equivalent to one of Quasi-noncombustible Materials. 3) Without layer of vapor-barrier, it is pcssible to stop the dew condensation in the insides of walls, because of humidity control performance of this insulator.