文献一覧: 池川信夫 (著者)

1 0 0 0 OA Withanolideの合成と生理活性

著者: 池川信夫平山匡男蒲生啓司
出版者: The Society of Synthetic Organic Chemistry, Japan
雑誌: 有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日: vol.41, no.10, pp.941-957, 1983 (Released:2010-01-22)
参考文献数: 76
被引用文献数: 2 2

Withanolide, a group of naturally occuring C28 steroidal lactone isolated from the plants of Solanaceae family, has been paid attention for their biological activity, e. g. antitumor and insect antifeedant. The syntheses of jaborosalactones, withaferin A and other several withanolides were achieved. The key steps in the synthesis involve introduction of the desired substituent at C-25 and stereoselective construction of the A/B rings by a facile allyl sulfoxide-sulfenate rearrangement. The biological activities and neighbouring group effects of the A/B ring are also described.