7 0 0 0 OA 点眼の滴下成功率と滴下部位のビデオ解析
- 著者
- 池田 博昭 高本 彩音 池田 純子 河野 清尊 中妻 章 徳村 忠一 森 久美子 飯原 なおみ 芳地 一 二宮 昌樹
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- pp.20-00136, (Released:2020-09-29)
- 参考文献数
- 23
- 被引用文献数
- 2
We investigated the success rates of eyedrop instillation and the distance between the cornea and the dropper tip in 100 volunteers using high-speed digital video recording. Past eyedrop adherence studies assumed that instillation occurred without failure. The ideal distance between the cornea and dropper tip remained unclear, although the general estimate was approximately 2.54 cm (1 inch). This study was approved by the Institutional Review Boards of all participating medical institutions, and all volunteers provided written, informed consent. Successful instillation was defined as when 1 drop fell accurately into the eye on the first attempt. The instillation of ≥2 drops or drops delivered outside the eye was considered a failure. The distance between the eye and dropper tip was measured using still images from a paused digital video camera and a digital ruler. Forty percent of the volunteers instilled eyedrops without instructions from ophthalmologists, pharmacists, or other healthcare workers. When the images were analyzed, the success rate of the first instillation was 70.1%. When the eye was arbitrarily divided into 9 sections, most of the drop sites were the iris or the center of the eye. The distance between the dropper tip and cornea was 2.62 ± 1.75 (median 2.20) cm. These results indicate that the generally recommended distance is usually followed. The successful instillation rate based on the distance from the dropper tip to the cornea was 77% at 1.6 ± 0.88 cm and 54.9% at 4.8 ± 1.25 cm.
2 0 0 0 OA 遊星ボールミルがセルロースナノファイバーゾルに与える物理化学的影響と表面活性
- 著者
- 高井(山下) 千加 馬渕 裕也 池田 純子 藤 正督 仙名 保 大矢 豊
- 出版者
- 一般社団法人 粉体工学会
- 雑誌
- 粉体工学会誌 (ISSN:03866157)
- 巻号頁・発行日
- vol.58, no.4, pp.164-169, 2021-04-10 (Released:2021-05-21)
- 参考文献数
- 16
- 被引用文献数
- 1 1
Mechanochemistry offers sustainable synthesis of the functionalized cellulose nanofiber (CNF). In this study, changes in the microstructure of the CNF aqueous sol by planetary ball milling were investigated in terms of its rheological behavior, crystallinity, and diameter distribution. The surface activity of the CNF was additionally characterized by a pulsed nuclear magnetic resonance (NMR). A decreased thixotropy hysteresis loop observed in the 100 min−1-treated CNFs indicated a weaker interaction among the fibers, but still having a three-dimensional structure. 300 min−1 could collapse them. A decreased x-ray diffraction peak intensity observed in the 500-min−1-treated CNF could indicate a split in the fiber’s bundle as well as shredding. An increase in the wet surface area (SNMR) could indicate surface activity in the 500-min−1 milled CNF sol. Such newly formed hydroxyl groups can serve as effective reaction sites with, for example, the TiO2 precursor and perhaps favorably works to improve the photocatalytic performance.
2 0 0 0 OA 点眼の滴下成功率と滴下部位のビデオ解析
- 著者
- 池田 博昭 高本 彩音 池田 純子 河野 清尊 中妻 章 徳村 忠一 森 久美子 飯原 なおみ 芳地 一 二宮 昌樹
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.140, no.12, pp.1455-1462, 2020-12-01 (Released:2020-12-01)
- 参考文献数
- 23
- 被引用文献数
- 2
We investigated the success rates of eyedrop instillation and the distance between the cornea and the dropper tip in 100 volunteers using high-speed digital video recording. Past eyedrop adherence studies assumed that instillation occurred without failure. The ideal distance between the cornea and dropper tip remained unclear, although the general estimate was approximately 2.54 cm (1 inch). This study was approved by the Institutional Review Boards of all participating medical institutions, and all volunteers provided written, informed consent. Successful instillation was defined as when 1 drop fell accurately into the eye on the first attempt. The instillation of ≥2 drops or drops delivered outside the eye was considered a failure. The distance between the eye and dropper tip was measured using still images from a paused digital video camera and a digital ruler. Forty percent of the volunteers instilled eyedrops without instructions from ophthalmologists, pharmacists, or other healthcare workers. When the images were analyzed, the success rate of the first instillation was 70.1%. When the eye was arbitrarily divided into 9 sections, most of the drop sites were the iris or the center of the eye. The distance between the dropper tip and cornea was 2.62±1.75 (median 2.20) cm. These results indicate that the generally recommended distance is usually followed. The successful instillation rate based on the distance from the dropper tip to the cornea was 77% at 1.6±0.88 cm and 54.9% at 4.8±1.25 cm.