著者
田中 康一
出版者
人文地理学会
雑誌
人文地理 (ISSN:00187216)
巻号頁・発行日
vol.47, no.5, pp.417-438, 1995
被引用文献数
2 1

The author's purpose was to elucidate the mechanisms of the location and transfer of the headquarters of an enterprise.The author did a case study on an enterprise and used several kinds of numerical indicators and written statements from annual financial reports, corporate history book and other materials about the enterprise to explain the reasons for and the processes of the location and transfer of functional departments of its corporate headquarters, including those for purchasing, production control, sales, personnel, finance, general accounting, planning, general affairs, and the strategic decision making, with the help of theories of business management.For example, the transition of the financial ratios and the spatial distribution of financial sources of the enterprise were used to explain the location and transfer of its Finance Dept. and the transition of the spatial distribution of labor was used to explain those of its Personnel Dept.The implications resulting from the analysis of the differences and similarities between the transferring processes of those functional departments greatly helped to extract some common and important rules for the location and transfer of functional departments of the corporate headquarters.In this empirical analysis, Snow Brand Milk Products Co., Ltd. (founded in 1925), Japan's largest dairy products company, was selected as a case study.The main reasons for choosing this enterprise were the abundant data concerning its financing and location since its foundation, and its experience in transferring its headquarters from the city of Sapporo, the largest city of Hokkaido, the northernmost of Japan's four main islands, to the capital city of Tokyo, the location of the nation's largest money market, most of the headquarters of the nation's largest banks and of other private and/or public organizations, the most important market for selling products, and the location with the most efficient access for transportation, communication and information processing.The facts found in the empirical study are summarized as follows:1. Until the company established its management base in the Hokkaido area, its financing depended on the local financial institutions and its Finance Dept. was located in Sapporo. But, as the company gradually expanded its operational space nationally, the volume of financial demand dramatically increased and came to depend on large financial institutions based in Tokyo and finally the Finance Dept. was transferred to Tokyo. Its gradual transfer started in 1958, just before the company started its nation-wide expansion, and took about two years to finish. Simultaneously, the transfer of the General Accounting Dept., the Planning Dept., and the Board of Directors occurred.2. As the locations of its plants and sales offices expanded nationally, the distribution of its labor also dispersed nationally. Accordingly the Production Control Dept. and the Personnel Dept., transferred to Tokyo, seeking for the most efficient access infrastructure to secure a national scale of transportation, telecommunication and information processing. As for the Personnel Dept., its gradual transfer started in 1958 and took more than seven years to finish and for Production Dept. about 10years, while the Sales Dept. had been located in Tokyo since the foundation of the enterprise.3. The General Affairs Dept. transferred following the locational shift of other departments.4. These transferring processes all involved a gradual transfer of authority from Sapporo to Tokyo and a spatial division of business management/administration both between and within functional departments was observed.Possible rules for the location of the functional departments based on the facts above are as follows:1. The location of a corporate headquarters is subject to the location of its functional departments.
著者
田中 康一
出版者
(財)東京都老人総合研究所
雑誌
基盤研究(C)
巻号頁・発行日
1996

大脳皮質シナプスにおけるアセチルコリン合成活性やそのレベルには加齢変化はないものの、脱分極刺激によるアセチルコリン放出が老齢シナプスにおいて低下することが種の違いを超えて認められた。この老齢シナプスにおけるアセチルコリン放出低下は、放出のトリガーとなるカルシウムイオン流入低下によることがカルシウムイオン蛍光指示薬を用いた実験で明らかとなったため,シナプスにおける電位依存性カルシウムチャネル(VDCC)の加齢変化を調べることを目的とした。大脳皮質シナプス膜のVDCCサブタイプの分布を各サブタイプに特異的なブロッカーを用いて調べたところ、L型チャネルが27%,N型チャネルが32%,P型チャネルが27%,Q型チャネルが23%であった。個体の老化によってP型チャネルの分布は全VDCCの16%となり,成熟期のラットに比べて著しく減少していた。さらに,シナプス膜への放射標識ブロッカーの結合実験によって,VDCC密度の加齢変化を検討した。その結果,25ヶ月齢では、L型,N型,Q型チャネルのBmax値,すなわち最大結合サイト数が6ヶ月齢に比べそれぞれ50%,35%,52%と顕著に減少していた。このVDCC密度の減少が、カルシウムイオン流入低下の直接の要因となっていることが推察された。また,L型チャネルブロッカー結合に対するKd値が老齢シナプスで成熟動物シナプスに比べて大きな値を示すことが認められた。この結果は、L型チャネルのブロッカーを結合するサブユニット(おそらく、α1サブユニット)の加齢による構造変化を反映している可能性を示唆していると思われる。以上,本研究の結果から、大脳皮質コリン作動性シナプスにおけるアセチルコリン放出低下とそれに伴うシナプス可塑性の加齢低下の根底には、電位依存性カルシウムチャネルの分布や密度の異常が関与していることが強く示唆された。