著者

加藤 貴彦 藤原 悠基 中下 千尋 盧 渓 久田 文 宮崎 航 東 賢一 谷川 真理 内山 巌雄 欅田 尚樹

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.1, pp.94-99, 2016 (Released:2016-01-30)

参考文献数

10

被引用文献数

1 3

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Multiple chemical sensitivity (MCS) is an acquired chronic disorder characterized by nonspecific symptoms in multiple organ systems associated with exposure to low-level chemicals. Diagnosis of MCS can be difficult because of the inability to assess the causal relationship between exposure and symptoms. No standardized objective measures for the identification of MCS and no precise definition of this disorder have been established. Recent technological advances in mass spectrometry have significantly improved our capacity to obtain more data from each biological sample. Metabolomics comprises the methods and techniques that are used to determine the small-level molecules in biofluids and tissues. The metabolomic profile—the metabolome—has multiple applications in many biological sciences, including the development of new diagnostic tools for medicine. We performed metabolomics to detect the difference between 9 patients with MCS and 9 controls. We identified 183 substances whose levels were beyond the normal detection limit. The most prominent differences included significant increases in the levels of both hexanoic acid and pelargonic acid, and also a significant decrease in the level of acetylcarnitine in patients with MCS. In conclusion, using metabolomics analysis, we uncovered a hitherto unrecognized alteration in the levels of metabolites in MCS. These changes may have important biological implications and may have a significant potential for use as biomarkers.

著者

宮崎 航 盧 渓 小田 政子 黒田 嘉紀 青木 一雄 三渕 浩 大場 隆 加藤 貴彦

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.2, pp.138-148, 2016 (Released:2016-05-27)

参考文献数

24

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Objectives: The incidence of infant allergic diseases have increased recently, and it may be caused by multiple influences of both genetic and environmental factors from the fetal stage through infancy. In this study, we analyzed a data subset from the South Kyushu and Okinawa (SKO) Study Area of Japan Environment and Children’s Study (JECS) to determine the relationship of allergic diseases in infants with mothers’ characteristics and/or infants’ life habits, especially sleeping. Methods: A total of 3873 mother-infant pairs from the SKO Regional Center of JECS were included. The mothers responded to questionnaires in the first trimester of their pregnancy and the self-reported questionnaire when their infants were 1 year old. Student’s t-test, chi-square test, trend test, and logistic regression analysis were carried out to analyze the associations between the infants’ allergic diseases and the mothers’ genetic characteristics and/or sleeping habits of infants. Results: Maternal allergic diseases were significantly associated with increased infant allergy risk (OR: 1.93, 95% CI: 1.63–2.27). The number of allergic diseases of mothers was also significantly associated with infant allergy, and the trend test showed an increasing risk of infant allergy (p<0.001). Regarding infants’ life habits, the infants who sleep in the prone position had a higher allergic disease risk than those who sleep in other positions (OR: 1.46, 95% CI: 1.17–1.83). These significant associations were observed regardless of the presence of allergy in mothers. Conclusions: This study suggests that the development of allergic diseases in infants may be caused by the multiple participation of both genetic and environmental factors.

著者

加藤 貴彦 松尾 佳奈 黒田 庄一郎 盧 渓 小田 政子 大場 隆

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.69, no.3, pp.211-214, 2014 (Released:2014-09-24)

参考文献数

3

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In a long-term large cohort study, we introduced an electronic money system for remuneration of research participants. In comparison with the delivery of cash vouchers, the operation and mailing cost, and the processing time were significantly reduced. The workers were also able to save the time and effort they spent on the inventory management of cash vouchers. In addition, risk management was improved, as demonstrated by the reduction of complaints and associated problems such as nonarrival or content differences of cash vouchers. This is because only card points as additional money need to be added once the electronic money card has been distributed to the recipients. Furthermore, the psychological stress of workers associated with inventory management and ensuring cash voucher enclosure was also reduced.