著者

加藤 貴彦 藤原 悠基 中下 千尋 盧 渓 久田 文 宮崎 航 東 賢一 谷川 真理 内山 巌雄 欅田 尚樹

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.1, pp.94-99, 2016 (Released:2016-01-30)

参考文献数

10

被引用文献数

1 3

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Multiple chemical sensitivity (MCS) is an acquired chronic disorder characterized by nonspecific symptoms in multiple organ systems associated with exposure to low-level chemicals. Diagnosis of MCS can be difficult because of the inability to assess the causal relationship between exposure and symptoms. No standardized objective measures for the identification of MCS and no precise definition of this disorder have been established. Recent technological advances in mass spectrometry have significantly improved our capacity to obtain more data from each biological sample. Metabolomics comprises the methods and techniques that are used to determine the small-level molecules in biofluids and tissues. The metabolomic profile—the metabolome—has multiple applications in many biological sciences, including the development of new diagnostic tools for medicine. We performed metabolomics to detect the difference between 9 patients with MCS and 9 controls. We identified 183 substances whose levels were beyond the normal detection limit. The most prominent differences included significant increases in the levels of both hexanoic acid and pelargonic acid, and also a significant decrease in the level of acetylcarnitine in patients with MCS. In conclusion, using metabolomics analysis, we uncovered a hitherto unrecognized alteration in the levels of metabolites in MCS. These changes may have important biological implications and may have a significant potential for use as biomarkers.

著者

藤原 悠基

出版者

群馬大学

雑誌

研究活動スタート支援

巻号頁・発行日

2020-09-11

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本研究は農薬等で使用されるネオニコチノイドによるヒト中枢神経系分化・発達への影響を解析する。これまで、実験動物を用いた研究から、周産期のネオニコチノイド曝露が中枢神経系の発育・発達を阻害する可能性が報告されているが、ヒトへの影響は明らかでない。また、中枢神経系の分化・発達と同時期に構築され始める血液脳関門(BBB)への影響を検討した報告はない。以上から、ネオニコチノイド曝露による影響を「ヒト胎児由来神経前駆細胞株を用いた神経分化」、「BBB透過性及び機能」の2点から評価することで、ネオニコチノイド曝露による胎児脳神経系の発達、発育への影響とその機序の解明を目指す。