著者

石川 敏三 仲西 修 掛田 崇寛 山本 美佐 古川 昭栄 伊吹 京秀 徳田 信子 石川 浩三 鈴木 秀典

出版者

山口大学

雑誌

基盤研究(C)

巻号頁・発行日

2012-04-01

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慢性疼痛はしばしば不安や鬱を併発し、極めて難治性である。そこで、痛覚ー情動系における分子メカニズムを解明し、また神経栄養因子(BDNF)治療応用について検討した。その結果、前帯状回や脳幹部(網様体)におけるモノアミン変調に随伴したBDNFの機能低下が慢性疼痛や気分障害に関連すること、またカテーコール化合物や磁気治療の有用性が判明した。慢性疼痛の治療法に新たな指針を提唱するものと考えられる。

著者

山本 悟 西 光晴 佐々木 宏典 石川 浩三 安田 聖子 澄川 泰弘 岸下 裕輔 井田 唯香 吉田 充広 掛田 崇寛 石川 敏三

出版者

日本疼痛学会

雑誌

PAIN RESEARCH (ISSN:09158588)

巻号頁・発行日

vol.26, no.4, pp.215-221, 2011-12-10 (Released:2013-03-16)

参考文献数

17

被引用文献数

1 1

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We have newly developed a low-powered magnetic stimulator (MS) that is characterized by two different frequency modes: 2 kHz (low frequency) and 83 MHz (ultra-short wave). It is suggested that MS reduces rat neuropathic pain associated with the prevention of neuronal degeneration. However, little is known about certain mechanisms of MS, at least, applicable value of the analgesic approaches in clinical situation. Thus, we aimed to determine the analgesic effects of MS in human with shoulder stiffness. We recruited volunteers with shoulder stiffness (MS was applied once for 10 min.) and with acute pain (MS was applied once a day (10 min period) for 9 days. The trial study on analgesic effects in human of new magnetic therapeutic instrument (Angel Touch®) were examined. We examined safety of MS based on electrocardiographic testing and body surface temperature. By using the heart rate on the electrocardiogram, we used FFT analyzer to analyze low frequency components (LH: 0.05 - 0.15Hz) and high frequency components (HF: 0.15 - 0.45 Hz). Muscle shoulder stiffness has been improved by the continued irradiation without a thermal action. Based on the present study, we suggest that MS has beneficial analgesic effects in human, and that MS will be a useful approach to treatment for neurodegenerative disorder because it may relieve pain via improvement of functional modulation of pain-emotional system.