著者
北村 謙始 山田 久美子 伊藤 明 福田 實
出版者
The Society of Cosmetic Chemists of Japan
雑誌
日本化粧品技術者会誌 (ISSN:03875253)
巻号頁・発行日
vol.29, no.2, pp.133-145, 1995-09-10 (Released:2010-08-06)
参考文献数
19
被引用文献数
14 13

With the purpose of clarifying the role of internal factors in the process of dry skin occurs, dry skin was induced experimentally by an ionic surfactant and, using the model system, we investiglated from a pharmacological perspective as a new experimental plan. Through this research, we have conceived a new theory explaining how dry skin occurs. Furthermore, on the beais of this theory, we have developed a new effective compound for its treatment.In order to study on the mechanism by which dry skin occurs, we used anti-inflammatory agents and inhibitors against histological impairment mediators, as well as various substances that were considered to regulate the function of epidermal cells. The results strongly suggested that the occurence of dry skin involves a cause bringing about the over-manifestation of the epidermal plasminogen (PLG) activation system, which in turn causes abnormalities in the regulating mechanisms for the proliferation and differentiation of epidermal cells, and these result in dry skin.We discovered 4-aminomethylcyclohexanecarboxylic acid (t-AMCHA), which was the most effective substance in view of the theory on the occurrence of dry skin. Then we investigated in detail the efficacy of t-AMCHA. The results of our studies confirmed that t-AMCHA strongly suppresses the over-manifestatation of the PLG activation system in the epidermis when dry skin was occurring. In addition, t-AMCHA demonstrated superb effectiveness against phenomena caused by dry skin, including the loss of moisture from the horny layer, the increase in transepidermal water loss (TEWL), accelerated turnover in the horny layer, and the changes in various other indicators such as epidermal hypertrophy.We also performed a double-blind trial on a preparation containing t-AMCHA. Results demonstrated that the preparation containing t-AMCHA definitely made better and faster improvement than the preparation without t-AMCHA in skin surface texture. Furthermore, the t-AMCHA containing preparation showed superior stability and safety and had excellent usability.We demonstrated for the first time that the intraepidermal PLG activation system plays a major role in the process by which dry skin occurs, and founded a new theory on the occurrence of dry skin. In addition, on the basis of this theory, we discovered the effective substance t-AMCHA and conducted research on its practical application. As a result, we have not only verified the theory but also developed a revolutionary new effective substance for cosmetics.
著者
福田 實
出版者
The Society of Cosmetic Chemists of Japan
雑誌
日本化粧品技術者会誌 (ISSN:03875253)
巻号頁・発行日
vol.31, no.4, pp.385-395, 1997

紫外線防御化粧品には紫外線防御効果が表示されている。UVBに対する防御効果はSPF (Sun Protection Factor) が, UVAに対する防御効果はPA gradeで表示されている。これらの表示の根幹を構成するのが, 紫外線防御効果の測定方法で, 日本では日本化粧品工業連合会技術委員会傘下の専門委員会が基準策定にあたった。SPF測定法基準は、SPF専門委員会により1992年1月に発効し, UVA防止効果測定法基準は, 世界で最初に, 紫外線専門委員会により, 1996年1月に発効された。<br>現在, 世界の何処の国でも, 統一されたUVBとUVAの2つの防御効果測定基準を持つ国はない。これら基準を策定する過程で, SPF専門委員会並びに紫外線専門委員会で検討し, 決定するに至った主な条項に解説を加えると共に, 紫外線防御化粧品の評価と表示方法について諸外国の現状を日本と対比しながら概説した。
著者
長沼 雅子 八木 栄一郎 山瀬 由記 福田 實
出版者
公益社団法人 日本皮膚科学会
雑誌
日本皮膚科学会雑誌 (ISSN:0021499X)
巻号頁・発行日
vol.105, no.11, pp.1427, 1995 (Released:2014-08-13)

紫外線感受性の性差を求めるため,紫外線曝露をほとんど受けていないと考えられる上腕内側を測定部位とし,主としてUVBを放射する蛍光灯と主としてUVAを放射する蛍光灯を各々2本組み合わせ光源とし,最少紅斑量(MED)の測定を行った.その結果皮膚色に性差は認められなかったが,MEDは有意に男性の方が低かった.これが紫外線の慢性的な傷害である日光角化症や有棘細胞癌の男性での発症率の高さの一因と考えた.