7 0 0 0 OA 薬物の腟吸収
- 著者
- 酒井 孝範 粟田 則男
- 出版者
- The Japanese Society for the Study of Xenobiotics
- 雑誌
- 薬物動態 (ISSN:09161139)
- 巻号頁・発行日
- vol.8, no.2, pp.263-272, 1993-04-10 (Released:2007-03-29)
- 参考文献数
- 23
The vagina is an important area of the reproductive tract. The vaginal route of administration of drugs may be a viable alternative to oral theraphy. But the vaginal preparations on the market are exclusively restricted to those are topically effective. Most of agents in vaginal preparations act directory on the vaginal membrane. Vaginal absorption is characterized by the avoidance of hepatic first pass effect, prolonged retention of the blood level and the variation throughout the reproductive cycle. In this minireview, the vaginal absorption of several drugs with low molecular weight is introduced from the standpoint of chemical structure, first pass effect and transport process. In addition, we discuss the vaginal absorption of prasterone sulfate(PS)in rats. PS is almost completely absorbed from the vagina. PS may be transported through vaginal membranes by both paracellular route and carriermediated process.
1 0 0 0 OA 塩酸アセブトロールの多形
- 著者
- 粟田 則男 山本 恵一 中川 寛 杉本 功 坂田 英彦 佐藤 久
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.99, no.2, pp.141-145, 1979-02-25 (Released:2008-05-30)
- 参考文献数
- 11
- 被引用文献数
- 1 2
Acebutolol hydrochloride was proved by thermal analysis (DTA and TG), IR spectra, and X-ray powder diffraction to have three crystalline forms (form I, II, and III) and an amorphous form. The amorphous form, which was stored at 20°under 91% R.H., was first transformed to forms II and III, and then it was finally transformed to form I. During this transformation, the incorporation and release of water were examined. Form I was stable at this condition, while form II was transformed to form I for 48 hr, and form III was transformed to form I for 2 hr. Further, it was found that the amorphous form was transformed to form II at 80°under 50% R.H. for 3 hr, but at 80°under vacuum it was transformed to form III. Form I at 138°for 8 hr and form III at 130°for 4 hr were transformed to form II. From these results it was concluded that form I was the most stable form at room temperature.