著者

阿部 隆三 及川 真一 佐野 隆一 藤井 豊 義江 和子 後藤 由夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.12, no.4, pp.951-956, 1984

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In the present study, effect of probucol (500mg×2, daily) on serum lipids and lipoproteins in S. F. family who showed typical familial hyper-cholesterolemia (FH) were investigated. The results were as follows:<br>1) The values of serum cholesterol (TC) before and after treatment of probucol were 348±14mg/dl and 220±12mg/dl, respectively. These data shows significant reduction of serum cholesterol after treatment of probucol. The percent of reduction of serum cholesterol was 36.4%. This value was significantly higher than the value (17%) in the other FH.<br>2) Though levels of LDL- and HDL-C were decreased after treatment of probucol, LDL-C level was markedly decrease in S. F family as compared with other FH. Reduction of HDL-C after treatment of probucol was not significant difference between in S. F family and other FH.<br>3) Total biliary lipids after treatment of probucol increased from 68.8μmol/ml to 141.9μmol/ml in a patient of S. F family. Level of bile acid increased after treatment of probucol, especially, in this case. On the other hand, the change of biliary lipids after treatment of probucol was not seen in other FH.<br>From these data, though mechanism of marked reduction of LDL-C in S. F family after treatment of probucol was still unclear, metabolism of cholesterol to synthesis of bile acid might have especially involved to marked reduction of serum LDL-C in S. F family.

著者

小竹 英俊 及川 眞一 生井 一之 佐久間 恵理子 義江 和子 豊田 隆謙

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.17, no.3, pp.453-456, 1989

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It has been established previously that low density lipoprotein (LDL) incubated with cultured endothelial cells, smooth muscle cells, or macrophages undergo a free radical-catalyzed oxidative modification. This modification involves lipid peroxides and extensive structural changes in the LDL molecule. The oxidatively modified LDL inhibits the motility of the mouse resident peritoneal macrophages, yet lysophosphatidylcholine in oxidized LDL acts as a chemotactic factor for circulating human monocytes. The present study demonstrated that the stimulation of human mononuclear cells with phorbol myristate acetate (PMA) results in an increase of oxidized LDL, which was assayed by LPO-KIT (obtained from Kyowa Hakko Inc.) in the culture medium. The medium containing oxidized LDL did not exhibit a chemotactic for human monocytes, but inhibited the chemotactic responses of monocytes to the N-formyl peptide and aortic extract.<br>These findings suggest that circulating monocytes may play a role in the subendothelial space by some chemotactic factors and become trapped in the splace due to the inhibitory effects of oxidatively modified LDL.

著者

佐野 隆一 藤井 豊 義江 和子 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.13, no.2, pp.349-353, 1985

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Three dysbetalipoproteinemic subjects with the E 2/2 homozygous phenotype were analysed serum lipoproteins and serum apolipoprotein E and B levels. Two subjects were normocholesterolemic and one was hypercholesterolemic (type III hyperlipoproteinemia). A patient with type III phenotype had cholesterol-rich VLDL, although the other two normocholesterolemic subjects didn't have it. Both normo- and hypercholesterolemic subjects had elevated levels of serum apo E and a reduction in serum apo B. Therefore, serum apo E/apo B ratio of a patient with type III phenotype was extremely high as compared with other lipoprotein disorders. These ratio of normocholesterolemic dysbetalipoproteinemia was also high as compared with those except for type V hyperlipoproteinemia. It is suggested that dysbetalipoproteinemia might be easily caught in general population by screening examination of serum apo E/apo B ratio.