著者

小林 正義 佐野 隆一 藤井 豊 及川 真一 阿部 隆三 後藤 由夫 山内 祐一

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.14, no.5, pp.1155-1160, 1986-12-01 (Released:2011-09-21)

参考文献数

16

---

Lipids metabolism during prolonged fasting (10-days complete fasting) has been studied in 23 psychosomatic patients (9 male and 14 female, average 29.2 y. o.), who had no metabolic disease.During the fasting period, serum F.F.A. and Cholesterol levels significantly elevated (p<0.001).In the lipoprotein fraction, LDL-cholesterol and LDL-triglyceride (d: 1.006-1.063) significantly elevated by fasting (p<0.001), but VLDL-triglyceri de (d;<1.006) decreased (p<0.05).The increase of LDL reflected the increase of LDL2-fraction (d; 1.019-1.063), and this was related to thyroid hormone levels. T3 levels decreased during prolonged fasting (p<0.01).It was considered that increase of LDL was related to the decrease of LDL-receptor activity which was dependent on T3-levels.

著者

後藤 由夫 阿部 隆三 及川 真一 佐野 隆一 藤井 豊

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.12, no.6, pp.1351-1357, 1985

著者

阿部 隆三 及川 真一 佐野 隆一 藤井 豊 義江 和子 後藤 由夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.12, no.4, pp.951-956, 1984

---

In the present study, effect of probucol (500mg×2, daily) on serum lipids and lipoproteins in S. F. family who showed typical familial hyper-cholesterolemia (FH) were investigated. The results were as follows:<br>1) The values of serum cholesterol (TC) before and after treatment of probucol were 348±14mg/dl and 220±12mg/dl, respectively. These data shows significant reduction of serum cholesterol after treatment of probucol. The percent of reduction of serum cholesterol was 36.4%. This value was significantly higher than the value (17%) in the other FH.<br>2) Though levels of LDL- and HDL-C were decreased after treatment of probucol, LDL-C level was markedly decrease in S. F family as compared with other FH. Reduction of HDL-C after treatment of probucol was not significant difference between in S. F family and other FH.<br>3) Total biliary lipids after treatment of probucol increased from 68.8μmol/ml to 141.9μmol/ml in a patient of S. F family. Level of bile acid increased after treatment of probucol, especially, in this case. On the other hand, the change of biliary lipids after treatment of probucol was not seen in other FH.<br>From these data, though mechanism of marked reduction of LDL-C in S. F family after treatment of probucol was still unclear, metabolism of cholesterol to synthesis of bile acid might have especially involved to marked reduction of serum LDL-C in S. F family.

著者

佐野 隆一 藤井 豊 義江 和子 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.13, no.2, pp.349-353, 1985

---

Three dysbetalipoproteinemic subjects with the E 2/2 homozygous phenotype were analysed serum lipoproteins and serum apolipoprotein E and B levels. Two subjects were normocholesterolemic and one was hypercholesterolemic (type III hyperlipoproteinemia). A patient with type III phenotype had cholesterol-rich VLDL, although the other two normocholesterolemic subjects didn't have it. Both normo- and hypercholesterolemic subjects had elevated levels of serum apo E and a reduction in serum apo B. Therefore, serum apo E/apo B ratio of a patient with type III phenotype was extremely high as compared with other lipoprotein disorders. These ratio of normocholesterolemic dysbetalipoproteinemia was also high as compared with those except for type V hyperlipoproteinemia. It is suggested that dysbetalipoproteinemia might be easily caught in general population by screening examination of serum apo E/apo B ratio.

著者

佐野 隆一 阿部 隆三 平川 秀紀 金沢 義彦 小泉 勝 豊田 隆謙 後藤 由夫 及川 真一

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.11, no.3, pp.671-676, 1983

---

In the present study, the effect of probucol (500mg×2, daily) on serum lipids and lipoproteirs level were studied in 9 patients with familial hypercholesterolemia (FH) during 3-4 months. The diagnosis of FH was established according to the criteria both of Fredrickson et al and of Makuchi et al. Thickness of Achilles tendon was over 9mm in all patients and the xanthomas were observed in 4 of 9 patients.<br>Before and 3-4 months after treatment of probucol the measurement of serum triglyceride (TG), total cholesterol (TC) and apolipoprotein (Apo) A-I and A-II were made. At the same time, serum VLDL, LDL, HDL₂ and HDL₃ were separated by successive ultracentrifugation. Thereafter, TG, TC and protein of each lipoprotein fraction were measured.<br>TG and TC were determined by enzymatic method, Apo A-I and A-II were done by single immunodiffusion assay, and protein was done by dye-binding method.<br>All data were expressed as mean ±S.E. and statistically analized by Student's t-test.<br>The results were as follows:<br>1) VLDL-TG levels were slightly increased, although no significance was found between VLDL-TG level before and after treatment.<br>2) The levels of serum TC were 388±37mg/dl and 308±28mg/dl (-21%, p<0.05) before and after probucol administration, respectively. LDL-cholesterol (LDL-C) levels decreased from 325±37mg/dl before treatment to 262±32mg/dl (-19%, p<0.05) after treatment. HDL-C values significantly decreased from 42±5mg/dl to 26±4mg/dl (-38%, p<0.01), and especially HDL₂-C showed significant fall (-48%, p<0.01).<br>3) Serum Lecithin: Cholesterol Acyltransferase (LCAT) activities were not changed.<br>4) The concentrations of Apo LDL decreased from 139±18mg/dl to 106±17mg/dl (-29%), but it was not significant statistically. Apo A-I levels decreased significantly from 92±10mg/dl to 66±10mg/dl (-28%, p<0.01). On the other hand, Apo A-II levels were unchanged.<br>These observations suggested that probucol would be a useful drug to improve serum and LDL cholesterol levels in FH. However, we should take care to use this drug because of its effect on HDL metabolism.

著者

藤井 豊 鈴木 教敬 堀 三郎 佐野 隆一 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化

巻号頁・発行日

vol.13, no.6, pp.1385-1387, 1986

---

Diabetes mellitus is frequently complicated with atherosclerosis. PWV (pulse wave velocity) is an indicator for the sclerotic change of thoratic and abdominal aorta. We studied the relation between PWV and lipid metabolism in diabetics.<br>The subjects who took part in this study were 54 diabetics who were aged from 50 to 59 years old and had a duration of illness over 5 years. Fasting blood sugar level and the concentration of glycosylated hemoglobin (HbA₁) were measured. Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), apo B and apo A-I were measured by enzymatic methods and SRID, respectively. PWV was measured by the methods of Hasegawa, et al.<br>We concluded that (1) PWV increased in poorly controlled diabetics (FBS 180mg/dl) more than in well controlled diabetics (FBS 119mg/dl), and (2) PWV had significant positive-relation to serum TC, TG, apo B, apo A-I and apo B/A-I ratio, and had significant negative-relation to HDL-C.<br>According to these data we should improve not only glucose metabolism but also derangement of lipid metabolism.

著者

佐野 隆一 阿部 隆三 及川 真一 藤井 豊 後藤 由夫 高瀬 貞夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.15, no.4, pp.1005-1008, 1987

---

The lipid levels of serum and lipoproteins were examined in eleven patients with myotonic dystrophy (MD) and ten normal subjects. Hyperlipoproteinemia was seen in six patients, including type IIb of three patients, type IIa of two and type V of one. Total cholesterol (C) and triglyceride (TG) levels of serum and lipoproteins in MD were not significant. TG/C ratio of lipoproteins in MD were not so high compared with normals.<br>The mean age of the patients with hyperlipoproteinemia was significantly higher than that of normolipoproteinemia. The correlation coefficients between age and lipid levels of serum and lipoproteins were examined. The age was positively correlated to serum C and VLDL-TG levels. Further, in the MD patients except for case 1 with type V hyperlipoproteinemia, the age was positively correlated to LDL-TG and LDL-C levels, and negatively correlated to HDL-TG levels.<br>In conclusion, the LDL levels increased and the HDL levels decreased with age in MD. These results suggest that the abnormalities of serum lipid metabolism is one of the characteristic changes in MD.